FlyBase Allele Report: Dmel\Akt[HM04007]

General Information

Symbol

Dmel\Akt^HM04007

Species

D. melanogaster

Name

FlyBase ID

FBal0245310

Feature type

allele

Associated gene

Dmel\Akt

Associated Insertion(s)

Carried in Construct

P{TRiP.HM04007}

Also Known As

Akt RNAi, UAS-Akt^RNAi, UAS-AKT-RNAi, UAS-akt RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.HM04007}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM04007

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

abnormal size | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

mechanosensory neuron of posterior dorsocentral bristle, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

neuron projection | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

synapse | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in rough and misshapen eye phenotype.

(Pletcher et al., 2019)

Posterior dorsocentral bristle neurons expressing Akt1^HM04007 under the control of Scer\GAL4^pnr-MD237 show a significantly decreased terminal arbor territory and significantly fewer synapses (Syt1 puncta) on the contralateral collateral branch, as compared to controls.

(Urwyler et al., 2019)

Mid-third instar larvae expressing Akt1^HM04007 in the fat body in the fat body under the control of Scer\GAL4^DcG exhibit moderately increased haemolymph glucose levels.

Mid-third instar larvae expressing Akt1^HM04007 in muscle under the control of Scer\GAL4^Mef2.PU exhibit moderately increased haemolymph glucose levels.

(Ugrankar et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Akt^HM04007, Scer\GAL4^pnr-MD237 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by PRL-1^UAS.cPa, Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

Akt^HM04007, Scer\GAL4^pnr-MD237 has abnormal size | adult stage phenotype, non-suppressible by PRL-1^UAS.cPa, Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

Suppressor of

Statement

Reference

Akt^HM04007, Scer\GAL4^ppk.PG is a suppressor of abnormal neuroanatomy | pupal stage phenotype of Cul1^GD9650, Scer\GAL4^ppk.PG

(Wong et al., 2013)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Akt^HM04007, Scer\GAL4^pnr-MD237 has mechanosensory neuron of posterior dorsocentral bristle phenotype, non-suppressible by PRL-1^UAS.cPa, Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

Akt^HM04007, Scer\GAL4^pnr-MD237 has neuron projection | adult stage phenotype, non-suppressible by PRL-1^UAS.cPa, Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

Akt^HM04007, Scer\GAL4^pnr-MD237 has synapse | adult stage phenotype, non-suppressible by PRL-1^UAS.cPa, Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

Suppressor of

Statement

Reference

Akt^HM04007, Scer\GAL4^ppk.PG is a suppressor of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Cul1^GD9650, Scer\GAL4^ppk.PG

(Wong et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Akt1^HM04007 dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19^GD9650 under the control of Scer\GAL4^ppk.PG at 16 hours after pupariation.

(Wong et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31701

y¹ v¹; P{TRiP.HM04007}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Akt1^HM04007

Akt^HM04007

Name Synonyms

Secondary FlyBase IDs

References (26)

Report Sections

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