FB2025_01 , released February 20, 2025
Allele: Dmel\Dop1R1HM04077
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General Information
Symbol
Dmel\Dop1R1HM04077
Species
D. melanogaster
Name
FlyBase ID
FBal0245374
Feature type
allele
Associated gene
Dmel\Dop1R1
Associated Insertion(s)
Carried in Construct
P{TRiP.HM04077}
Also Known As
Dop1R1-RNAi, UAS-DopR1-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.HM04077}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HM04077
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Dop1R1HM04077 under the control of Scer\GAL4Clk.-856 (together with Dicer-2, for efficient RNAi) leads to decreased activity during daytime.

      Expression under the control of Scer\GAL4Pdf.PU (together with Dicer-2, for efficient RNAi) leads to decreased daytime sleep amount; daytime sleep bouts are more frequent but shorter.

      Expression under the control of Scer\GAL4Pdf.Switch1a induced by and RU486 (and together with Dicer-2 for efficient RNAi) leads to decreased daytime sleep amount, with decreased daytime sleep bout duration. There is increased daytime and nighttime activity.

      (Fernandez-Chiappe et al., 2020)

      Down-regulation of DopR through expression of DopRHM04077 under the control of Scer\GAL4elav-C155 does not affect the larval feeding rate.

      (Neckameyer and Bhatt, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dop1R1HM04077
      Dop1R1RNAi
      (Kacsoh et al., 2019)
      DopRHM04077
      Name Synonyms
      Secondary FlyBase IDs
        References (15)