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General Information
Symbol
Dmel\JraJF01184
Species
D. melanogaster
Name
FlyBase ID
FBal0245476
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of JraJF01184 under the control of Scer\GAL4P2.4.Pdf in the presence of Dcr-2Scer\UAS.cDa (which increases RNAi efficiency) does not affect the period of locomotor activity (measured in flies kept under constant darkness conditions).

Expression of JraJF01184 under the control of Scer\GAL4Hand.ΔVM.Switch (initiated by feeding flies RU486 during adulthood) results in improved cardiac function compared to controls. Heart period (mean time between successive end-diastolic positions) and frequency of arrhythmicity are reduced at both 10 and 45 days compared to age-matched controls. No difference from controls is seen in three day-old flies. Expression of JraJF01184 also prevents the age-related decrease in End-Diastolic Diameter (EDD) seen in wild type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
JraJF01184
JraRNAiJF01184
Name Synonyms
Secondary FlyBase IDs
    References (7)