FB2025_01 , released February 20, 2025
Allele: Dmel\Stat92EJF01265
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General Information
Symbol
Dmel\Stat92EJF01265
Species
D. melanogaster
Name
FlyBase ID
FBal0245557
Feature type
allele
Associated gene
Dmel\Stat92E
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01265}
Also Known As
UAS-Stat92E RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01265}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01265
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  colorectal cancer
      modeled by UvragHMS01357
      (Nagy et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Stat92EJF01265 under the control of Scer\GAL4Stat92E-0092-G4 (in combination with tub-Gal80[ts] to restrict expression to the adult stage) leads to an increase in the presynaptic bouton number and disruptions in the actin cytoskeleton of the STAT-expressing pars intercerebralis neurons in the adult brain.

      (Brent and Rajan, 2020)

      The adulthood-only expression of Stat92EJF01265 under the control of Scer\GAL4esg-NP5130 (and Gal80[ts], for the temporal control of expression) leads to a severe increase in mitotic index and to a significant increase in the number of intestinal stem cells/enteroblasts in the adult midgut epithelium, as compared to controls.

      (Nagy et al., 2016)

      Expression of Stat92EJF01265 under the control of Scer\GAL4en-e16E results in ectopic wing veins. The phenotype is more severe in males than females.

      (Ni et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of Stat92EJF01265 suppresses both the increased numbers of intestinal stem cells/enteroblast and the increased mitotic index induced in the adult midgut epithelium by the adulthood-only expression of UvragHMS01357 under the control of Scer\GAL4esg-NP5130 (and Gal80[ts]).

      (Nagy et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Stat92EJF01265
      Name Synonyms
      Secondary FlyBase IDs
        References (10)