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General Information
Symbol
Dmel\twunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0246009
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous and twunspecified/Df(1)Exel6223 adults show significantly decreased climbing ability compared to control flies. The mutant flies also have reduced flight ability compared to controls. The general locomotive activities of hemizygous flies are not significantly different from wild type.

    Mutant larvae show abnormalities in the body wall muscles, with defects in muscle patterning often being seen, and muscles occasionally being missing.

    Mutant adults have ultrastructural defects in the thoracic and leg muscles. Sarcomeric disarray is often seen, Z-lines are irregular and often streaming, actin and myosin filaments are disorganised and accumulations of glycogen granules are seen. Enlarged mitochondria and swollen sarcoplasmic reticulum are seen between the muscle fibres. The basement membrane is duplicated and multilayered. Muscle defects are seen in both 15- and 35-day old adults, but are more frequent in the older flies.

    The wing disc area occupied by myoblasts in mutant thid larval instar discs is less than that in control disc. However, the number of myoblast per unit area of tissue is higher in the mutant discs than in the control discs, and as a result, the total number of myoblasts per disc is not significantly different in mutant and wild-type discs. The number of apoptotic myoblasts is 2.4 fold higher in mutant wing discs than in controls, while the number of dividing myoblasts per disc is not different in mutant and wild-type discs.

    Crosses of heterozygous females to hemizygous males result in significantly lower mutant adults than expected, indicating a reduction in viability.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    The reduced flying ability of twunspecified animals and ultrastructural defects seen in the leg and thoracic muscles are completely rescued by expression of twScer\UAS.cUa under the control of Scer\GAL4Act5C.PU.

    The reduced viability of twunspecified animals is rescued by expression of twScer\UAS.cUa under the control of Scer\GAL4Act5C.PU.

    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    twunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (1)