Allele Dmel\mahj¹

General Information
Symbol	Dmel\mahj¹	Species	D. melanogaster
Name		FlyBase ID	FBal0246066
Feature type	allele	Associated gene	Dmel\mahj

Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Tamori et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{GT1}CR42547^GT-000304 (Tamori et al., 2010)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion, resulting in a 1633bp deletion that includes part of exon 9, exons 10 and 11 and the 3' UTR of mahj. (Tamori et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	developmental rate defective (Tamori et al., 2010) developmental rate defective (with Df(2R)XE-2900) (Tamori et al., 2010) increased cell death \| cell non-autonomous \| somatic clone (Tamori et al., 2010) lethal (with Df(2R)XE-2900) (Tamori et al., 2010) lethal \| pupal stage (Tamori et al., 2010)
Phenotype Manifest In
	wing disc \| cell non-autonomous \| somatic clone (Tamori et al., 2010)
Detailed Description
	Statement Reference Homozygous and mahj[1]/Df(2R)XE-2900 animals develop more slowly than normal. Homozygous larvae do not have any detectable morphological defects. Analysis of homozygous clones in the wing disc shows that 72 hours after clone induction, both homozygous and wild-type sibling clones are readily detected. However, at 96 hours after clone induction, the homozygous clones are smaller than the sibling clones, and by 120 hours after clone induction, most of the homozygous clones have disappeared from the wing disc epithelium. Homozygous cells adjacent to wild type or heterozygous cells frequently undergo apoptosis, whereas homozygous cells that are not adjacent to wild type or heterozygous cells rarely undergo apoptosis. The majority of apoptotic cells are basally extruded from the disc epithelium, but some remain within the epithelial layer. Basally extruded homozygous cells which are not apoptotic are also sometimes seen. (Tamori et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference mahj¹ has increased cell death \| somatic clone phenotype, suppressible \| somatic clone by puc^Scer\UAS.cMa/Scer\GAL4^tub.PU (Tamori et al., 2010) mahj¹ has increased cell death \| somatic clone phenotype, suppressible \| somatic clone by Scer\GAL4^tub.PU/BacA\p35^Scer\UAS.cHa (Tamori et al., 2010)
NOT suppressed by
Statement Reference mahj¹ has increased cell death \| somatic clone phenotype, non-suppressible \| somatic clone by Scer\GAL4^tub.PU/l(2)gl^{Scer\UAS.T:Hsap\MYC} (Tamori et al., 2010)
Phenotype Manifest In
Suppressed by
Statement Reference mahj¹ has wing disc \| somatic clone phenotype, suppressible \| partially \| somatic clone by puc^Scer\UAS.cMa/Scer\GAL4^tub.PU (Tamori et al., 2010) mahj¹ has wing disc \| somatic clone phenotype, suppressible \| partially \| somatic clone by Scer\GAL4^tub.PU/BacA\p35^Scer\UAS.cHa (Tamori et al., 2010)
NOT suppressed by
Statement Reference mahj¹ has wing disc \| somatic clone phenotype, non-suppressible \| somatic clone by Scer\GAL4^tub.PU/l(2)gl^{Scer\UAS.T:Hsap\MYC} (Tamori et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Expression of puc[Scer\UAS.cMa] under the control of Scer\GAL4[tub.PU] strongly suppresses the apoptosis that is seen in mahj[1] clones in the wing disc. Basal extrusion of mutant cells is not fully blocked in these discs. Expression of l(2)gl[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[tub.PU] does not affect the phenotype of mahj[1] clones in the wing disc; the cells undergo apoptosis and are basally extruded. (Tamori et al., 2010)
Xenogenetic Interactions
Statement Reference Expression of BacA\p35[Scer\UAS.cHa] under the control of Scer\GAL4[tub.PU] strongly suppresses the apoptosis that is seen in mahj[1] clones in the wing disc. Basal extrusion of mutant cells is not fully blocked in these discs. (Tamori et al., 2010)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	mahj¹ (Tamori et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Tamori et al., 2010, PLoS Biol. 8(7): e1000422 Involvement of Lgl and Mahjong/VprBP in Cell Competition. [FBrf0211298]

Allele Dmel\mahj1

Allele Dmel\mahj¹