Allele Dmel\Rel^{68.Scer\UAS.T:Zzzz\FLAG}

General Information
Symbol	Dmel\Rel^{68.Scer\UAS.T:Zzzz\FLAG}	Species	D. melanogaster
Name		FlyBase ID	FBal0246191
Feature type	allele	Associated gene	Dmel\Rel

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Wiklund et al., 2009) in vitro construct - regulatory fusion (Wiklund et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS drives expression of a 68 kDa N-terminal fragment of Rel, which represents the 'active' cleavage product of full-length Rel, tagged with T:Zzzz\FLAG. (Wang et al., 2012) Scer\UAS regulatory sequences drive expression of amino acid residues 1-545 of Rel (the "REL-68" product) which is tagged at the N-terminal end with T:Zzzz\FLAG. (Wiklund et al., 2009)
Carried in construct	P{UAS-FLAG-Rel.68} (Wang et al., 2012, Wiklund et al., 2009)
Tagged with	T:Zzzz\FLAG (Wiklund et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage, with Scer\GAL4^da.G32 (Wang et al., 2012)
Phenotype Manifest In

Detailed Description
	Statement Reference Larvae expressing Rel[68.Scer\UAS.T:Zzzz\FLAG] under the control of either Scer\GAL4[fat] or Scer\GAL4[C7] have increased levels of triacylglycerols compared to wild type. (Rynes et al., 2012) Scer\GAL4[da.G32], Rel[68.Scer\UAS.T:Zzzz\FLAG] flies develop normally but many are unable to eclose. (Wang et al., 2012)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Rel^{68.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^da.G32 has lethal \| pupal stage phenotype, enhanceable by mtd^Scer\UAS.RC, Scer\GAL4^da.G32 (Wang et al., 2012)
Suppressed by
Statement Reference Rel^{68.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^da.G32 has lethal \| pupal stage phenotype, suppressible by mtd^Scer\UAS.RH, Scer\GAL4^da.G32 (Wang et al., 2012)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Co-expression of mtd[Scer\UAS.RH] rescues the eclosion defect of Scer\GAL4[da.G32], Rel[68.Scer\UAS.T:Zzzz\FLAG] flies. Co-expression of mtd[Scer\UAS.RC] exacerbates the eclosion defect of Scer\GAL4[da.G32], Rel[68.Scer\UAS.T:Zzzz\FLAG] flies. (Wang et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Rel-68 (Rynes et al., 2012) Rel^{68.Scer\UAS.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Rynes et al., 2012, Mol. Cell. Biol. 32(19): 3949--3962 Activating transcription factor 3 regulates immune and metabolic homeostasis. [FBrf0219385] Wang et al., 2012, J. Immunol. 188(8): 3993--4000 The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway. [FBrf0217978] Wiklund et al., 2009, Dev. Comp. Immunol. 33(5): 690--696 The N-terminal half of the Drosophila Rel/NF-kappaB factor Relish, REL-68, constitutively activates transcription of specific Relish target genes. [FBrf0207341]

Allele Dmel\Rel68.Scer\UAS.T:Zzzz\FLAG

Allele Dmel\Rel^{68.Scer\UAS.T:Zzzz\FLAG}