FB2025_01 , released February 20, 2025
Allele: Dmel\fblL.UAS
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General Information
Symbol
Dmel\fblL.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0246209
Feature type
allele
Associated gene
Dmel\fbl
Associated Insertion(s)
Carried in Construct
P{UAS-fbl.L}
Key Links
Transgenic product class
wild_type
(Wu et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2009)
Mutagen
in vitro construct
(Wu et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-fbl.L}
Cytology
Description

UAS regulatory sequences drive expression of the long isoform of fbl (known as fbl-RE in FlyBase).

(Wu et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fbl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease 6
      modeled by Pink1RNAi.UAS.cYa
      (Huang et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act.PU/fblL.UAS rescues fbl1

      (Wu et al., 2009)
      Partially rescues

      Scer\GAL4elav.PU/fblL.UAS partially rescues fbl1

      (Wu et al., 2009)

      fblL.UAS/Scer\GAL4Ddc.PL partially rescues fbl1

      (Wu et al., 2009)

      fblL.UAS/Scer\GAL4ChAT.7.4 partially rescues fbl1

      (Wu et al., 2009)
      Comments

      Expression of fblL.Scer\UAS under the control of Scer\GAL4Act.PU rescues the eclosion defects of fbl1 flies, and the lifespan of these animals recovers to almost normal levels. Locomotor and infertility defects are also rescued in these animals.

      Expression of fblL.Scer\UAS under the control of Scer\GAL4elav.PU in a fbl1 mutant background rescues the eclosion defects, shortened lifespan and movement coordination defects of fbl1 flies, but does not rescue infertility.

      Expression of fblL.Scer\UAS in dopaminergic neurons under the control of Scer\GAL4Ddc.PL partially rescues the eclosion rate, shortened lifespan, and locomotor defects of fbl1 mutant flies.

      Expression of fblL.Scer\UAS in cholinergic neurons under the control of Scer\GAL4Cha.7.4 partially rescues the eclosion rate, shortened lifespan, and locomotor defects of fbl1 mutant flies.

      (Wu et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fblL.Scer\UAS
      fblL.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)