Allele Dmel\th^Scer\UAS.cBa

General Information
Symbol	Dmel\th^Scer\UAS.cBa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Betz	FlyBase ID	FBal0246254
Feature type	allele	Associated gene	Dmel\th

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Betz et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of th. (Betz et al., 2008)
Carried in construct	P{UAS-th.B} (Betz et al., 2008, Liu et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4^C57 (Liu et al., 2010)
Phenotype Manifest In
	synapse, with Scer\GAL4^C57 (Liu et al., 2010)
Detailed Description
	Statement Reference Overexpression of BacA\p35[Scer\UAS.cHa] in presynaptic neurons under the control of Scer\GAL4[OK6] has no obvious effect on synapse elimination. Overexpression of BacA\p35[Scer\UAS.cHa] in postsynaptic neurons under the control of Scer\GAL4[C57] results in strong arrest of synapse elimination at 9 hours after puparium formation. (Liu et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^tub.PU/th^Scer\UAS.cBa is a suppressor of increased cell death \| conditional \| third instar larval stage phenotype of Stat92E³⁹⁷ (Betz et al., 2008)
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^tub.PU/th^Scer\UAS.cBa is a suppressor of wing disc \| conditional \| third instar larval stage phenotype of Stat92E³⁹⁷ (Betz et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference When th[Scer\UAS.cBa] is over-expressed in the wing disc under the control of Scer\GAL4[tub.PU] from first instar larval stage (by heat-shock induction to inactivate Scer\GAL80[αTub84B.PL]), Stat92E[397] mutant clones take up 7.7% of the wing pouch after x-irradiation treatment (5,000 rads daily for 3 days). Low levels of cell death are observed. (Betz et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	th^Scer\UAS.cBa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Betz
Secondary FlyBase IDs

References ( 2 )
Research paper	Liu et al., 2010, J. Neurosci. 30(35): 11624--11634 Distinct Presynaptic and Postsynaptic Dismantling Processes of Drosophila Neuromuscular Junctions during Metamorphosis. [FBrf0211694] Betz et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105(37): 13805--13810 STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis. [FBrf0205996]

Allele Dmel\thScer\UAS.cBa

Allele Dmel\th^Scer\UAS.cBa