Allele Hsap\APP^Aβ42.GMR

General Information
Symbol	Hsap\APP^Aβ42.GMR	Species	H. sapiens
Name		FlyBase ID	FBal0246257
Feature type	allele	Associated gene	Hsap\APP

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Finelli et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference GMR drives expression of the Aβ[[42]] peptide with the pre-proenkephalin signal sequence derived from Hsap\APP. (Finelli et al., 2004)
Carried in construct	P{GMR-APP.Aβ42} (Cao et al., 2008, Finelli et al., 2004, Lee et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	size defective (Finelli et al., 2004) visible (Finelli et al., 2004, Lee et al., 2011)
Phenotype Manifest In
	eye (Finelli et al., 2004, Cao et al., 2008, Lee et al., 2011) eye photoreceptor cell (Finelli et al., 2004) interommatidial bristle (Finelli et al., 2004) ommatidium (Finelli et al., 2004)
Detailed Description
	Statement Reference Expression of Hsap\APP[Aβ42.GMR] results in profound eye degeneration. Feeding flies with linoleic acid and linolenic acid ameliorates the eye degeneration caused by Hsap\APP[Aβ42.GMR]. In contrast, campesterol or γ-linolenic acid feeding does not induce any prominent changes. (Lee et al., 2011) Flies develop a rough eye phenotype. (Cao et al., 2008) Adult eyes show different degrees of eye disorganization (depending on the insertion line and the number of insertions), ranging from slight abnormalities to fusion of ommatidia and missing inter-ommatidial bristles. Eyes appear 'glazed' and are noticeably reduced in size in the most severe cases. In sections, irregular, smaller ommatidia with abnormal, degenerating photoreceptors are observed, with numerous gaps in the tissue . There are no intact ommatidia in the most severe cases - only occasional residual photoreceptors are seen, with large tissue gaps. No gross morphological defects are seen in third instar imaginal discs from Hsap\APP[Aβ42.GMR] (insertion line P{GMR-APP.Aβ42}K3) homozygous larvae. The rough, disorganized eye phenotype seen in freshly eclosed Hsap\APP[Aβ42.GMR] (insertion line P{GMR-APP.Aβ42}K3) heterozygous flies gets progressively more severe with time, reaching a plateau at 32 days. (Finelli et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by ATP7[+]/ATP7^EY07895 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by CG6767[+]/CG6767^KG00420 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by CG7231^EP2510/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by CG11006[+]/Sap130^EY12079 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by cwo^EP3470/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Dsp1^EP355/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by elB[+]/elB⁹ (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by elB^EP965/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by EP330[+]/EP330^EP330 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by EP1504[+]/EP1504^EP1504 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by esg^EP684/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by HDAC4^KG09091/HDAC4[+] (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Ide^EP3099/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by mub[+]/mub^EP3108 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Nep2[+]/Nep2^KG05754 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by P{EP}CG6745^EP595b/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by P{EP}ckd^EP3041/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Rpd3⁰⁴⁵⁵⁶/Rpd3[+] (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Scer\GAL4^ey.PU/MESR4^EP386 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹ (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by SNF4Agamma[+]/SNF4Aγ^KG10152 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by SNF4Aγ^EP3015b/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by svr¹²⁶/svr[+] (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by svr^EP356/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by svr^KG02090/svr[+] (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, enhanceable by Tl^EP1051/Scer\GAL4^ey.PU (Cao et al., 2008)
NOT Enhanced by
Statement Reference Hsap\APP^Aβ42.GMR has eye phenotype, non-enhanceable by CG2924[+]/CG2924^EY02142 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, non-enhanceable by mub⁰⁴⁰⁹³/mub[+] (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, non-enhanceable by UbcD4[+]/UbcD4^EY05497 (Cao et al., 2008)
Suppressed by
Statement Reference Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by CG2924[+]/CG2924^EP1596 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by CG6175^EP3405/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by CG6767[+]/CG6767^EP3603 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by CG10347^EP308/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by EP1318^EP1318/Scer\GAL4^ey.PU (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by g[+]/g^B166 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by g[+]/g^EP514 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by Nep2^EP3549/Scer\GAL4^ey.PU (Finelli et al., 2004, Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, suppressible by Scer\GAL4^ey.PU/P{EP}Atg1^EP3348 (Cao et al., 2008)
NOT suppressed by
Statement Reference Hsap\APP^Aβ42.GMR has eye phenotype, non-suppressible by CG2924[+]/CG2924^EY02142 (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, non-suppressible by mub⁰⁴⁰⁹³/mub[+] (Cao et al., 2008) Hsap\APP^Aβ42.GMR has eye phenotype, non-suppressible by UbcD4[+]/UbcD4^EY05497 (Cao et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Co-expression of Nep2[EP3549] using Scer\GAL4[ey.PU] suppresses the Hsap\APP[Aβ42.GMR] rough eye phenotype. (Finelli et al., 2004)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\APP^Aβ42.GMR
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Lee et al., 2011, Mol. Cells 31(4): 337--342 The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. [FBrf0213599] Cao et al., 2008, Genetics 178(3): 1457--1471 Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. [FBrf0205107] Finelli et al., 2004, Mol. Cell. Neurosci. 26(3): 365--375 A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. [FBrf0179205]

Allele Hsap\APPAβ42.GMR

Allele Hsap\APP^Aβ42.GMR