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General Information
Symbol
Dmel\Drakdel
Species
D. melanogaster
Name
FlyBase ID
FBal0246418
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Deletion of Drak resulting from FLP-catalyzed recombination using the FRT-containing transposons PBac{WH}f07790 and PBac{RB}Drake03054.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Recombination between the two progenitor insertions has resulted in deletion of the genomic sequence between them, which removes almost the entire Drak gene without affecting neighbouring genes.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The wing area of homozygous flies is significantly smaller than that of controls, with the wings being specifically shortened in the proximal-distal axis. The mutant flies sometimes show shortening of the legs, usually restricted to the T3 leg; leg segments (primarily the femur and tibia) are shortened and abnormally bent.

Drakdel/DrakKO adults show a reduction in wing area compared to controls and a partially penetrant phenotype of T3 leg defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Drakdel has visible phenotype, enhanceable by Rho172O/Rho1[+]

Drakdel has visible phenotype, enhanceable by zip2/zip[+]

Drakdel has visible phenotype, enhanceable by Sb63b/Sb[+]

Suppressed by
Statement
Reference

Drakdel/DrakKO, rok[+]/Rok2 has lethal phenotype, suppressible by flwG0172/flwG0172

Drakdel/DrakKO, rok[+]/Rok2 has lethal phenotype, suppressible by sqhE20.E21

NOT suppressed by
Statement
Reference

Drakdel/DrakKO, rok[+]/Rok2 has lethal phenotype, non-suppressible by sqhA20.A21.Tag:FLAG

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Drakdel has wing phenotype, enhanceable by Rho172O/Rho1[+]

Drakdel has wing phenotype, enhanceable by zip2/zip[+]

Drakdel has wing phenotype, enhanceable by Sb63b/Sb[+]

Suppressed by
Statement
Reference
Suppressor of
Statement
Reference

Drakdel is a suppressor of wing phenotype of flwG0172/flwG0172

Other
Additional Comments
Genetic Interactions
Statement
Reference

The shortening of the wing which is seen in Drakdel flies is enhanced if the flies are also heterozygous for one of Rho172O, zip2 or Sb63b.

More than half of Drakdel rok2/Drakdel third instar larvae are missing random elements of the tracheal tree.

The wing discs of Drakdel rok2/DrakKO third instar larvae are composed of unusually thin epithelial layers which are grossly distorted. The wing pouch region has folds which project basally out of the plane of the epithelium, and these distortions are accompanied by massive apoptosis.

100% of Drakdel rok2 double homozygous embryos die before hatching. They show a fully penetrant head defect, which is characterized by an anterior hole in the embryonic cuticle and anterior malformations of the cephalopharyngeal skeleton.

The wing defects of flwG0172 escapers are suppressed by Drakdel. The T3 leg defects seen in Drakdel mutants are suppressed by flwG0172.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)