Allele Dmel\Ranbp11⁹

General Information
Symbol	Dmel\Ranbp11⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0246521
Feature type	allele	Associated gene	Dmel\Ranbp11

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Higashi-Kovtun et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: W49@. (Higashi-Kovtun et al., 2010) Ranbp11[9] contains a nonsense mutation before the Ran-binding domain, resulting in a heavily truncated protein. (Higashi-Kovtun et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pharate adult stage (with Df(2R)ΔM22-103) (Higashi-Kovtun et al., 2010) neurophysiology defective (Higashi-Kovtun et al., 2010) neurophysiology defective \| somatic clone (Higashi-Kovtun et al., 2010) phototaxis defective (Higashi-Kovtun et al., 2010)
Phenotype Manifest In

Detailed Description
	Statement Reference Ranbp11[9] flies exhibit defects in phototaxis and abnormalities in the ERG. Ranbp11[9] mutant eye clones lack 'on' and 'off' transients in their ERGs in response to brief exposures to light. (Higashi-Kovtun et al., 2010)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Ranbp11⁹ is rescued by Scer\GAL4^ey.PH/Ranbp11^{Scer\UAS.T:Avic\GFP-EGFP} (Higashi-Kovtun et al., 2010)
Comments	Expression of Ranbp11[Scer\UAS.T:Avic\GFP-EGFP] in photoreceptors under the control of Scer\GAL4[ey.PH] fully restores the on and off transients in Ranbp11[9] mutant eye clones. (Higashi-Kovtun et al., 2010)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	impβ11⁹ (Higashi-Kovtun et al., 2010) Ranbp11⁹
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Higashi-Kovtun et al., 2010, J. Neurosci. 30(15): 5253--5268 Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. [FBrf0210588]

Allele Dmel\Ranbp119

Allele Dmel\Ranbp11⁹