FB2025_01 , released February 20, 2025
Allele: Dmel\Cdc42UAS.cWa
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General Information
Symbol
Dmel\Cdc42UAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Warner
FlyBase ID
FBal0246544
Feature type
allele
Associated gene
Dmel\Cdc42
Associated Insertion(s)
Carried in Construct
P{UAS-Cdc42.W}
Also Known As
UAS-Cdc42
Key Links
Transgenic product class
wild_type
(Warner, 2010.9.15)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Warner, 2010.9.15)
Mutagen
in vitro construct
(Warner, 2010.9.15)
Progenitor genotype
Carried in construct
P{UAS-Cdc42.W}
Cytology
Description

UAS regulatory sequences drive expression of wild-type Cdc42.

(Warner, 2010.9.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Cdc42
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Cdc42Scer\UAS.cWa under the control of Scer\GAL4GMR.PU at 18[o]C leads to no obvious visible effects on the adult eye, as compared to controls.

      (Couturier et al., 2017)

      Overexpression of Cdc42Scer\UAS.cWa driven by Scer\GAL4sev.EP causes R-cell loss in adult eyes.

      (Dollar et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of Cdc42Scer\UAS.cWa in combination with RhoGEF3UAS.EKN.sfGFP, but not RhoGEF3KAA.UAS.sfGFP, under the control of Scer\GAL4GMR.PU leads to a fully penetrant pharate lethality that is associated with a very strong eye defect (residual eye), as compared to controls.

      (Couturier et al., 2017)

      R-cell loss in flies with Cdc42Scer\UAS.cWa driven by Scer\GAL4sev.EP is partially (but significantly) suppressible in the presence of FrlEx83/+, FrlEx88/+ or FrlExK62/+, and completely suppressible with co-expression of FrlDN.Scer\UAS.

      Co-expression of Cdc42Scer\UAS.cWa suppresses the ommatidial rotation phenotypes (planar cell polarity-like defects) seen in flies with FrlDN.Scer\UAS driven by Scer\GAL4sev.EP.

      (Dollar et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cdc42Scer\UAS.cWa
      Cdc42UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Warner
      Secondary FlyBase IDs
        References (5)