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General Information
Symbol
Dmel\shits.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0246565
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-shiTS, UAS-shits1, Shits, UAS-shibirets1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of dominant negative form of shi.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of shits.Scer\UAS.cUa under the control of Scer\GAL4upd-E132 at 29[o]C (restrictive temperature) lengthens the period of locomotor activity by approximately 0.7 hours under constant darkness conditions. Locomotor activity rhythms revert back to normal after the flies are shifted to 21[o]C (permissive temperature).

Expression of shits.Scer\UAS.cUa under the control of either Scer\GAL4ey.3.5.Exel or Scer\GAL4repo.PU at the restrictive temperature results in a glial overmigration phenotype in the eye disc.

Expression of shits.Scer\UAS.cUa in early to mid-third instar larvae under the control of any one of Scer\GAL4NP423, Scer\GAL4NP867 or Scer\GAL4NP394 leads to positive larval phototaxis at the restrictive temperature, whereas controls show negative phototaxis.

Animals carrying shits.Scer\UAS.cUa and Scer\GAL4repo.PU raised at 18[o]C and then subsequently shifted as adults to 30[o]C show 100% lethality within 3 days of the temperature shift.

Expression of shits.Scer\UAS.cUa under the control of Scer\GAL4Mz709 at 30[o]C strongly suppresses glial clearance of axonal debris from the central nervous system after severing of olfactory receptor neurons. Expression of shits.Scer\UAS.cUa under the control of Scer\GAL4alrm.PD at 30[o]C has no effect on axon debris clearance after severing of olfactory receptor neurons.

Animals carrying shits.Scer\UAS.cUa expressed under the control of Scer\GAL4en-e16E and shifted to the restrictive temperature of 31[o]C at the third larval instar show a dramatic induction of wing hairs. If the shift to the restrictive temperature occurs at 26 hours after puparium formation, a milder wing-hair duplication phenotype is seen in the resulting adults.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
shits.Scer\UAS.cUa
shits.UAS.cUa
Name Synonyms
Secondary FlyBase IDs
    References (26)