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General Information
Symbol
Dmel\kccUAS.cHb
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct b of Hekmat-Scafe
FlyBase ID
FBal0246596
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of the B isoform of kcc cDNA fragment from GH09271.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of kccScer\UAS.cHb under the control of Scer\GAL4CG31235.PS leads to a reduction in astrocyte infiltration of the neuropil in L1 larvae, and reduced locomotor performance as compared to controls, with some larvae exhibiting paralysis and non-responsiveness to mechanical stimuli.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Expression of kccScer\UAS.cHb driven by Scer\GAL4c739 significantly suppresses the bang-sensitive paralytic phenotype of eas2 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4c739 significantly suppresses the bang-sensitive paralytic phenotype of bss1 mutants.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of kccScer\UAS.cHb driven by Scer\GAL4repo.PU produces no apparent change in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4elav.PLu results in a substantial reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL41407 results in a substantial reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4ey-OK107 results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4Aph-4-c232 results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4104Y results only in a modest reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4GH146 results in a substantial reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Co-expression of Scer\GAL80Mef2.PT with Scer\GAL4elav.PLu-driven kccScer\UAS.cHb results in a significantly compromise in the rescuing ability of kccScer\UAS.cHb. Scer\GAL80Mef2.PT co-expression significantly compromises the ability of Scer\GAL4elav.PLu-driven kccScer\UAS.cHb to rescue the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4Mef2.247 results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4c747 results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Electrophysiology shows that Scer\GAL4c747-driven kccScer\UAS.cHb expression raises the seizure threshold of kccDHS1 mutant flies. Expression of kccScer\UAS.cHb driven by Scer\GAL4c739 results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4c305a results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4Tab2-201Y results in a marked reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4Rdl.PS results in a substantial reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4Gad1.3.098 results in a significant reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Expression of kccScer\UAS.cHb driven by Scer\GAL4Cha.7.4 results only in a modest reduction in the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
kccScer\UAS.cHb
kccUAS.cHb
Name Synonyms
Saccharomyces cerevisiae UAS construct b of Hekmat-Scafe
Secondary FlyBase IDs
    References (2)