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General Information
Symbol
Dmel\Rabex-5VDRC.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0246621
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an RNAi construct targeting Rabex-5.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Larvae and pupae expressing Rabex-5VDRC.cUa driven by strong, constitutive drivers die as giant larvae or giant pupae, often containing melanotic tumors.

Expression of Rabex-5VDRC.cUa driven by Scer\GAL4Act.PU results in viable adults with about a 10% increase in length, weight and wing size compared with controls.

Expression of Rabex-5VDRC.cUa driven by Scer\GAL4Act.PU or Scer\GAL4C-765 results in extra posterior crossveins and extra longitudinal veins compared to controls. Rabex-5ex42/+ enhances the wing phenotype resulting from Rabex-5VDRC.cUa expression driven by Scer\GAL4C-765.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

Rabex-5VDRC.cUa, Scer\GAL4Act.PU has wing vein L2 phenotype, suppressible by Ras85De1B/Ras85D[+]

Rabex-5VDRC.cUa, Scer\GAL4Act.PU has wing vein L2 phenotype, suppressible by Ras85De2F/Ras85D[+]

Rabex-5VDRC.cUa, Scer\GAL4C-765 has wing vein L2 phenotype, suppressible by Ras85De1B/Ras85D[+]

Dcr-2UAS.cDa, Rabex-5VDRC.cUa, Scer\GAL4ey.PU has eye phenotype, suppressible | partially by Ras85De1B/Ras85D[+]

Enhancer of
NOT Enhancer of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Rabex-5VDRC.cUa with Dcr-2Scer\UAS.cDa in the early eye driven by Scer\GAL4ey.PU leads to a fraction of the eyes with severe phenotypes, including overgrown eyes, outgrowths, small or lost eyes, and extra antennae.

Ras85De1B and Ras85De2F dominantly suppress the extra wing veins caused by constitutive expression of Rabex-5VDRC.cUa via Scer\GAL4Act.PU.

Ras85De1B dominantly suppresses the extra wing veins caused by wing-specific expression of Rabex-5VDRC.cUa via Scer\GAL4C-765.

A Ras85De1B/+ genetic background results in fewer flies with severe eye phenotypes upon co-expression of Rabex-5VDRC.cUa and Dcr-2Scer\UAS.cDa driven by Scer\GAL4ey.PU.

Ras85De1B dominantly suppresses the increased body size, body length and wing area resulting from the expression of Rabex-5VDRC.cUa driven by Scer\GAL4Act.PU. Body weight of all flies and wing area in female flies are no longer statistically different from controls.

Co-expression of Rabex-5VDRC.cUa significantly enhances the number of eyes with black tissue and significantly increases lethality resulting from the expression of Ras85DV12.S35.Scer\UAS driven by Scer\GAL4GMR.PU. The overgrowth, extra antennae, and ectopic eye phenotypes of Ras85DV12.S35.Scer\UAS overexpression are also enhanced by Rabex-5VDRC.cUa-expression.

Co-expression of Rabex-5VDRC.cUa significantly enhances the number of eyes with black tissue and significantly increases lethality resulting from the expression of EgfrU.A887T.Scer\UAS driven by Scer\GAL4GMR.PU.

Co-expression of Rabex-5VDRC.cUa fails to enhance the eye phenotypes resulting from the overexpression of phlScer\UAS.F179 driven by Scer\GAL4GMR.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

This construct is originally from the Vienna Drosophila RNAi Center (VDRC).

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Rabex-5VDRC.cUa
Name Synonyms
Secondary FlyBase IDs
    References (1)