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General Information
Symbol
Dmel\Rbsn-534
Species
D. melanogaster
Name
FlyBase ID
FBal0246678
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion has resulted in a 705bp deletion starting 80bp upstream of the Rbsn-5 5' UTR and covering the ATG codon and 372bp of the first exon of Rbsn-5. The deletion does not extend into the neighbouring CG8552 gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes (zygotic mutants) die during the first larval instar stage, while embryos lacking both maternal and zygotic Rbsn-5 function die early during embryogenesis.

Homozygous clones in the wing disc show defects in endocytosis.

Adult wings containing homozygous clones have patches of tissue with planar cell polarity defects; hairs are deflected from the proximodistal axis and orient towards either the posterior or anterior margin. Occasionally, cells within the presumed clone have double or shorter hairs than normal. Cells within homozygous clones in the pupal wing at pre-hair initiation consistently have emerging trichomes that are misoriented, pointing away from the clone, and the emerging hairs are shorter than in controls. Mutant cells fail to acquire the expected hexagonal shape. Mutant cells have a narrower apical cross section (characteristic of vein cells) in approximately 25% of clones, and these clones are usually adjacent to vein areas and positioned at the pupal wing border. Adult wings containing homozygous clones often have patches of extra or thickened wing veins. There is a weak proximal non-autonomy in trichome polarity, such that in proximal cells near to homozygous clones, trichomes point away from the clone, hexagonal packing is altered and occasionally cells abutting the clone are multi-haired.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Rbsn-534
Name Synonyms
Secondary FlyBase IDs
    References (1)