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General Information
Symbol
Dmel\SmBR1-7.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0246765
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of a mutant form of SmB in which all seven Arg residues in SmB (residues 112, 130, 145, 174, 181, 189 and 196) which are present in RG dipeptide repeats and can potentially be methylated have been substituted (either by Leu or Gly).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of SmBR1-7.Scer\UAS.P\T under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 32%. However, all the rescued flies are completely agametic. Although germ cells can migrate through the midgut epithelium in these embryos, they are unable to coalesce with the gonadal mesoderm.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
SmBR1-7.Scer\UAS.P\T
SmBR1-7.UASp
Name Synonyms
Secondary FlyBase IDs
    References (1)