Allele Dmel\trpm²⁸

General Information
Symbol	Dmel\trpm²⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0246783
Feature type	allele	Associated gene	Dmel\trpm
Also Known As	dTRPM²⁸

Allele class	amorphic allele - genetic evidence, hypomorphic allele - molecular evidence
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Georgiev et al., 2010) hypomorphic allele - molecular evidence (Georgiev et al., 2010)
Mutagen	Delta2-3 (Georgiev et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EPgy2}trpm^EY01618 (Georgiev et al., 2010)
Nature of the lesion	Statement Reference Imprecise excision of P{EPgy2}trpm[EY01618] that removes 2623 bp of the trpm sequence which includes exons 10-12 and about half of the adjacent introns. (Georgiev et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell size (Georgiev et al., 2010) developmental rate defective \| larval stage (Georgiev et al., 2010) lethal \| larval stage \| maternal effect (Georgiev et al., 2010) lethal \| prepupal stage (Georgiev et al., 2010) lethal \| prepupal stage \| recessive (Georgiev et al., 2010)
Phenotype Manifest In
	mitochondrion (Georgiev et al., 2010)
Detailed Description
	Statement Reference Mutant animals show prolonged larval development, at the end of which they arrest and die at the prepupal stage. The mutant larvae have a lower body weight compared to controls throughout larval development, with the difference in weight being greatest at the end of the second larval instar. Mutant animals lacking both maternal and zygotic function show an obvious growth defect by the end of the first larval instar, weighing less than controls. This defect progresses rapidly so that by the middle of the second instar they are approximately 17% the weight of controls. These larvae die approximately 48 hours after hatching. The growth defect seen in mutant animals is underpinned by a reduction in cell size, whereas cell numbers and DNA replication are normal. Mitochondria in mutant salivary glands are fused to form long tubular structures (in wild type they are seen as individual bullet-shaped structures). (Georgiev et al., 2010) Homozygotes die at the end of the larval stage, at the point of white prepupae formation. (Georgiev et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference trpm²⁸ is a suppressor of increased cell size phenotype of Pi3K92E^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^AB1 (Georgiev et al., 2010) trpm²⁸ is a suppressor of increased cell size phenotype of S6k^{STDETE.Scer\UAS}, Scer\GAL4^AB1 (Georgiev et al., 2010)
Phenotype Manifest In
Suppressor of
Statement Reference trpm²⁸ is a suppressor of embryonic/larval salivary gland phenotype of Pi3K92E^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^AB1 (Georgiev et al., 2010) trpm²⁸ is a suppressor of salivary gland phenotype of S6k^{STDETE.Scer\UAS}, Scer\GAL4^AB1 (Georgiev et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Expression of Pi3K92E[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[AB1] in a trpm[28] background does not result in an increase in cell size in the larval salivary gland. Expression of S6k[STDETE.Scer\UAS] under the control of Scer\GAL4[AB1] in a trpm[28] background does not result in an increase in cell size in the salivary gland. (Georgiev et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	dTRPM²⁸ (Georgiev et al., 2010, Georgiev et al., 2010) trpm²⁸
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Georgiev et al., 2010, Cell Metab. 12(4): 386--397 TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development. [FBrf0211938]
Supplementary material	Georgiev et al., 2010, Cell Metab. 12(4): TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development. Supplemental Information. [FBrf0212679]

Allele Dmel\trpm28

Allele Dmel\trpm²⁸