Allele Scer\GAL4^Mef2.247

General Information
Symbol	Scer\GAL4^Mef2.247	Species	S. cerevisiae
Name		FlyBase ID	FBal0246857
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms smell perception defective
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Zars et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\GAL4 expression is guided by a 247bp enhancer from a 2.2kb region 15kb upstream of Mef2. (Zars et al., 2000)
Carried in construct	P{Mef2-GAL4.247} (Kang et al., 2011, Li et al., 2011, Enell et al., 2010, Awasaki et al., 2011, Acebes et al., 2012, Houot et al., 2012, Sarthi and Elefant, 2011, Tan et al., 2010, Hekmat-Scafe et al., 2010, Wang et al., 2007, Baier et al., 2002, Schwaerzel et al., 2003, Baker et al., 2007, Kim et al., 2007, Zars et al., 2000, McGuire et al., 2001, Pitman et al., 2006, Isabel et al., 2004, McGuire et al., 2003, Ramaekers et al., 2005, Ashraf et al., 2006, Didelot et al., 2006, Robin et al., 2007, Grosjean et al., 2008, Poeck et al., 2008, Tzortzopoulos and Skoulakis, 2007, Yu et al., 2009, Brembs, 2009, Iliadi et al., 2008, Keleman et al., 2007, Krashes et al., 2007, Krashes et al., 2009, Scantlebury et al., 2010, Tanaka et al., 2008, Moressis et al., 2009, Lee and Wu, 2010, Knapek et al., 2011, Goguel et al., 2011, Acebes et al., 2011, Bang et al., 2011, Zhao et al., 2009, Donlea et al., 2009, Hou et al., 2011, Copf et al., 2011, Song et al., 2009, Christiansen et al., 2011, Ferris et al., 2006, Gouzi et al., 2011, Urizar et al., 2007, Zhang et al., 2007, Blum et al., 2009, Xia and Tully, 2007, Sudhakaran et al., 2012, Majumdar et al., 2012, Moraru et al., 2012, Carhan et al., 2005, Aso et al., 2009, Mosca et al., 2012, Zanini et al., 2012, Pfeiffenberger and Allada, 2012, Pauls et al., 2010, Pauls et al., 2010, Michels et al., 2011, Krüttner et al., 2012, Volders et al., 2012, Kaun et al., 2011, Chen et al., 2008, Ellis et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective \| heat sensitive, with shi^1.Scer\UAS (Pitman et al., 2006) behavior defective \| male, with Ctet\TeTxLC^{IMPTNT-Q.Scer\UAS} (Baier et al., 2002) behavior defective \| male, with Ctet\TeTxLC^TNT.Scer\UAS (Baier et al., 2002) courtship behavior defective, with qtc^GD8202 (Houot et al., 2012) courtship behavior defective, with Sh^GD13718 (Houot et al., 2012) learning defective, with drk^{dsRNA.Sym.Scer\UAS} (Moressis et al., 2009) lethal, with pum^Scer\UAS.cSa (Chen et al., 2008) lethal \| pupal stage, with Tip60^{dsRNA.Z.Scer\UAS} (Sarthi and Elefant, 2011) lethal \| pupal stage, with Tip60^{E431Q.Scer\UAS} (Sarthi and Elefant, 2011) memory defective, with brp^{dsRNA.B.Scer\UAS}, brp^{dsRNA.C.Scer\UAS} (Knapek et al., 2011) memory defective, with nemy^GD1646 (Iliadi et al., 2008) memory defective, with Phm^GD506 (Iliadi et al., 2008) memory defective, with Tequila^{dsRNA.Scer\UAS} (Didelot et al., 2006) memory defective \| heat sensitive, with shi^1.Scer\UAS (McGuire et al., 2001, Schwaerzel et al., 2003) neuroanatomy defective, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Acebes et al., 2011) neuroanatomy defective, with Ten-m^GD3620 (Mosca et al., 2012) neuroanatomy defective \| larval stage, with Tip60^{dsRNA.Z.Scer\UAS} (Sarthi and Elefant, 2011) neuroanatomy defective \| larval stage, with Tip60^{E431Q.Scer\UAS} (Sarthi and Elefant, 2011) smell perception defective \| heat sensitive, with Scer\GAL4^Tab2-201Y, shi^1.Scer\UAS (Kaun et al., 2011) temperature response defective \| adult stage, with Cyp6a17^{dsRNA.Scer\UAS.WIZ} (Kang et al., 2011) temperature response defective \| adult stage, with Mmus\Pkaca^mC.Scer\UAS (Kang et al., 2011)
Phenotype Manifest In
	intrinsic neuron, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Acebes et al., 2011) mushroom body, with sgg^Scer\UAS.cBa (Acebes et al., 2012) NMJ bouton, with Ten-m^GD3620 (Mosca et al., 2012) synapse, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Acebes et al., 2011) terminal bouton, with Tip60^{dsRNA.Z.Scer\UAS} (Sarthi and Elefant, 2011) terminal bouton, with Tip60^{E431Q.Scer\UAS} (Sarthi and Elefant, 2011) type I bouton \| ectopic, with Tip60^{dsRNA.Z.Scer\UAS} (Sarthi and Elefant, 2011) type I bouton \| ectopic, with Tip60^{E431Q.Scer\UAS} (Sarthi and Elefant, 2011) type Ib terminal bouton \| ectopic, with Tip60^{dsRNA.Z.Scer\UAS} (Sarthi and Elefant, 2011) type Ib terminal bouton \| ectopic, with Tip60^{E431Q.Scer\UAS} (Sarthi and Elefant, 2011) type Is terminal bouton, with Tip60^{dsRNA.Z.Scer\UAS} (Sarthi and Elefant, 2011) type Is terminal bouton, with Tip60^{E431Q.Scer\UAS} (Sarthi and Elefant, 2011)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference dlg1^{WT.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^Mef2.247 is a suppressor of neuroanatomy defective phenotype of slo¹ (Lee and Wu, 2010) Scer\GAL4^Mef2.247, orb2^{Scer\UAS.B.cKa}, Scer\GAL80^ts.αTub84B is a suppressor of courtship behavior defective \| adult stage phenotype of orb2::Mmus\Cpeb2^{RBD.T:Avic\GFP} (Krüttner et al., 2012) Scer\GAL4^Mef2.247, orb2^{Scer\UAS.B.cKa}, Scer\GAL80^ts.αTub84B is a suppressor of learning defective \| adult stage phenotype of orb2::Mmus\Cpeb2^{RBD.T:Avic\GFP} (Krüttner et al., 2012) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, Ctet\TeTxLC^Scer\UAS.cTa is a suppressor \| partially of paralytic \| recessive phenotype of kcc^DHS1 (Hekmat-Scafe et al., 2010)
NOT Suppressor of
Statement Reference Mmus\Nbea^Scer\UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of neuroanatomy defective \| adult stage phenotype of rg^FDD (Volders et al., 2012) Mmus\Nbea^Scer\UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of neuroanatomy defective \| adult stage phenotype of rg^γ5 (Volders et al., 2012) Scer\GAL4^Mef2.247, Scer\GAL80^ts.αTub84B, orb2^{RBD.Scer\UAS.B} is a non-suppressor of courtship behavior defective \| adult stage phenotype of orb2::Mmus\Cpeb2^{RBD.T:Avic\GFP} (Krüttner et al., 2012) Scer\GAL4^Mef2.247, Scer\GAL80^ts.αTub84B, orb2^{RBD.Scer\UAS.B} is a non-suppressor of learning defective \| adult stage phenotype of orb2::Mmus\Cpeb2^{RBD.T:Avic\GFP} (Krüttner et al., 2012)
Phenotype Manifest In
Suppressor of
Statement Reference dlg1^{WT.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^Mef2.247 is a suppressor of neuromuscular junction phenotype of slo¹ (Lee and Wu, 2010) dlg1^{WT.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^Mef2.247 is a suppressor of NMJ bouton \| supernumerary phenotype of slo¹ (Lee and Wu, 2010)
NOT Suppressor of
Statement Reference Mmus\Nbea^Scer\UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of adult mushroom body phenotype of rg^FDD (Volders et al., 2012) Mmus\Nbea^Scer\UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of adult mushroom body phenotype of rg^γ5 (Volders et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^Mef2.247, orb2^B.Scer\UAS, Scer\GAL4^Mef2.247 rescues orb2^ΔQ/orb2^Δ (Keleman et al., 2007) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, DopR^f02676 rescues DopR^f02676 (Kim et al., 2007) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, DopR^f02676 rescues In(3LR)234/DopR^f02676 (Kim et al., 2007) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, orb2^A.Scer\UAS rescues orb2^ΔQ/orb2^Δ (Keleman et al., 2007) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, rut^Scer\UAS.cZa rescues rut²⁰⁸⁰ (Zars et al., 2000) Scer\GAL4^Mef2.247/Cyp6a17^Scer\UAS.cKa rescues Cyp6a17^Δ173 (Kang et al., 2011) Scer\GAL4^Mef2.247/DopR^Scer\UAS.cBa rescues Df(3R)red-P52/+ (Bang et al., 2011) Scer\GAL4^Mef2.247/DopR^Scer\UAS.cBa rescues DopR^PL00420 (Bang et al., 2011) Scer\GAL4^Mef2.247/Syn^{1-12.Scer\UAS} rescues Syn⁹⁷ (Michels et al., 2011) Su(H)^Scer\UAS.cPa/Scer\GAL4^Mef2.247 rescues Su(H)⁸ (Song et al., 2009)
Partially rescues	Nrg^167.Scer\UAS/Scer\GAL4^Mef2.247 partially rescues Nrg^ibx (Carhan et al., 2005) Nrg^{180.I.Scer\UAS}/Scer\GAL4^Mef2.247 partially rescues Nrg^ibx (Carhan et al., 2005) Scer\GAL4^Mef2.247, RanBPM^{long.Scer\UAS}, Scer\GAL4^Mef2.247 partially rescues RanBPM^k05201 (Scantlebury et al., 2010) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, kcc^Scer\UAS.cHb partially rescues kcc^DHS1 (Hekmat-Scafe et al., 2010) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, RanBPM^S.Scer\UAS partially rescues RanBPM^k05201 (Scantlebury et al., 2010) Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, rut^Scer\UAS.cZa partially rescues rut²⁰⁸⁰ (Schwaerzel et al., 2003) Scer\GAL4^Mef2.247/gish^Scer\UAS.cTa partially rescues gish^MB896 (Tan et al., 2010) Scer\GAL4^Mef2.247/rg^Scer\UAS.cVa partially rescues rg^γ5 (Volders et al., 2012)
Fails to rescue	Scer\GAL4^Mef2.247, inc^f00285 fails to rescue inc^f00285 (Pfeiffenberger and Allada, 2012) Scer\GAL4^Mef2.247, Nf1^Scer\UAS.cWa, Scer\GAL80^ts.αTub84B fails to rescue Nf1^E1/Nf1^E2 (Gouzi et al., 2011) Scer\GAL4^Mef2.247/rg^Scer\UAS.cVa fails to rescue rg^FDD (Volders et al., 2012) Scer\GAL4^Mef2.247/Ten-a^Scer\UAS.cHa fails to rescue Df(1)Ten-a (Mosca et al., 2012)
Comments	Expression of Su(H)[Scer\UAS.cPa] under the control of Scer\GAL4[Mef2.247] (using the temperature sensitive Scer\GAL80[ts.αTub84B] allele to limit expression to the adult stage) rescues the reduced 24 hour memory phenotype seen in Su(H)[8] homozygotes. (Song et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Scer\GAL4²⁴⁷ Scer\GAL4^Mef2.247
Name Synonym
Secondary FlyBase IDs
	FBal0117652 FBal0155903 FBal0213103
References ( 71 )

Generate a list of	All references relating to this allele ( 71 )

List References by type	Research paper ( 66 ) Supplementary material ( 4 ) Review ( 1 )
Recent research papers ( 24 )
	Acebes et al., 2012, J. Neurosci. 32(2): 417--422 Central Adaptation to Odorants Depends on PI3K Levels in Local Interneurons of the Antennal Lobe. [FBrf0217241] Houot et al., 2012, PLoS ONE 7(1): e30799 Genes Involved in Sex Pheromone Discrimination in Drosophila melanogaster and Their Background-Dependent Effect. [FBrf0217343] Krüttner et al., 2012, Neuron 76(2): 383--395 Drosophila CPEB Orb2A Mediates Memory Independent of Its RNA-Binding Domain. [FBrf0219767] Majumdar et al., 2012, Cell 148(3): 515--529 Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. [FBrf0217407] Moraru et al., 2012, Neural Dev. 7(1): 14 Analysis of cell identity, morphology, apoptosis and mitotic activity in a primary neural cell culture system in Drosophila. [FBrf0218691] Mosca et al., 2012, Nature 484(7393): 237--241 Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. [FBrf0218053] Pfeiffenberger and Allada, 2012, PLoS Genet. 8(10): e1003003 Cul3 and the BTB Adaptor Insomniac Are Key Regulators of Sleep Homeostasis and a Dopamine Arousal Pathway in Drosophila. [FBrf0219613] Sudhakaran et al., 2012, J. Neurosci. 32(21): 7225--7231 Plasticity of recurrent inhibition in the Drosophila antennal lobe. [FBrf0218409] Volders et al., 2012, J. Neurosci. 32(43): 15193--15204 Drosophila rugose Is a Functional Homolog of Mammalian Neurobeachin and Affects Synaptic Architecture, Brain Morphology, and Associative Learning. [FBrf0219807] Zanini et al., 2012, Genes Brain Behav. 11(7): 819--827 Deletion of the Drosophila neuronal gene found in neurons disrupts brain anatomy and male courtship. [FBrf0219541] Acebes et al., 2011, J. Neurosci. 31(8): 2734--2745 Synapse loss in olfactory local interneurons modifies perception. [FBrf0213264] Bang et al., 2011, PLoS Genet. 7(3): e1001346 Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. [FBrf0213392] Christiansen et al., 2011, J. Neurosci. 31(26): 9696--9707 Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila. [FBrf0214059] Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Ellis et al., 2011, J. Cell Sci. 124(11): 1844--1856 In vivo functional analysis reveals specific roles for the integrin-binding sites of talin. [FBrf0213701] Goguel et al., 2011, J. Neurosci. 31(3): 1032--1037 Drosophila amyloid precursor protein-like is required for long-term memory. [FBrf0212809] Gouzi et al., 2011, PLoS Genet. 7(9): e1002281 The receptor tyrosine kinase alk controls neurofibromin functions in Drosophila growth and learning. [FBrf0216258] Hou et al., 2011, Nitric Oxide 24(1): 17--24 Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila. [FBrf0212726] Kang et al., 2011, PLoS ONE 6(12): e29800 Novel Cytochrome P450, cyp6a17, Is Required for Temperature Preference Behavior in Drosophila. [FBrf0217065] Kaun et al., 2011, Nat. Neurosci. 14(5): 612--619 A Drosophila model for alcohol reward. [FBrf0213574] Knapek et al., 2011, J. Neurosci. 31(9): 3453--3458 Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory. [FBrf0213189] Li et al., 2011, PLoS ONE 6(11): e28269 The hector G-Protein Coupled Receptor Is Required in a Subset of fruitless Neurons for Male Courtship Behavior. [FBrf0216834] Michels et al., 2011, Learn. Mem. 18(5): 332--344 Cellular site and molecular mode of synapsin action in associative learning. [FBrf0213538] Sarthi and Elefant, 2011, PLoS ONE 6(10): e26202 dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction. [FBrf0216592] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Scer\GAL4Mef2.247

Allele Scer\GAL4^Mef2.247