FlyBase Allele Report: Scer\GAL4[Mef2.247]

Drives expression in the whole of the alpha and beta lobes, with stronger expression being detected in the surface and posterior subdivisions. In the gamma lobe, the main body of the lobe stains stronger than the dorsomedial tip.

(FlyBase Curators, 2017)

Stains a large set of embryonic- and larval-born gamma neurons as well as glial cells in the ventral nerve cord.

(Pauls et al., 2010)

Expression of Scer\GAL4^Mef2.247 is stronger in the alpha/beta and gamma mushroom body lobes than in the alpha'/beta' mushroom body lobes.

(Tan et al., 2010)

Expression is limited to alpha, beta, and gamma neurons in the adult mushroom body.

(Blum et al., 2009)

In the mushroom body, Scer\GAL4^Mef2.247 drives expression in the whole of the alpha and beta lobes, with stronger expression being detected in the surface and posterior subdivisions. In the gamma lobe, the main body of the lobe stains stronger than the dorsomedial tip.

(Aso et al., 2009)

Expression is found in only a few alpha'/beta' neurons.

(Krashes et al., 2007)

Marker for

mushroom body

(Baier et al., 2002, McGuire et al., 2001, Zars et al., 2000)

Reflects expression of

Mef2

(Riemensperger et al., 2013, Tan et al., 2010, Zhao et al., 2009, Poeck et al., 2008, Tanaka et al., 2008, Krashes et al., 2007, Baier et al., 2002, McGuire et al., 2001, Zars et al., 2000)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | heat sensitive, with shi^1.UAS

(Pitman et al., 2006)

abnormal behavior | male, with Ctet\tetX^IMPTNT-Q.UAS

(Baier et al., 2002)

abnormal behavior | male, with Ctet\tetX^TNT-LC.UAS

(Baier et al., 2002)

abnormal cell migration | embryonic stage, with robo1^dsRNA.UAS

(Raza and Jacobs, 2016)

abnormal cell migration | embryonic stage, with robo2^dsRNA.UAS

(Raza and Jacobs, 2016)

abnormal courtship behavior, with qtc^GD8202

(Houot et al., 2012)

abnormal courtship behavior, with Sh^GD13718

(Houot et al., 2012)

abnormal courtship behavior | chemical conditional, with DopEcR^JF03415

(Aranda et al., 2017)

abnormal learning, with drk^{dsRNA.Sym.UAS}

(Moressis et al., 2009)

abnormal learning, with nsl1^NIG.4699R

(Koolen et al., 2012)

abnormal learning | adult stage, with CG4266^GD11266

(Fliedner et al., 2020)

abnormal learning | adult stage, with CG4266^HMC04041

(Fliedner et al., 2020)

abnormal learning | adult stage, with Fmr1^GD1288

(Kanellopoulos et al., 2012)

abnormal locomotor behavior | adult stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

abnormal locomotor behavior | adult stage | heat sensitive, with Scer\GAL4^GMR16A06, TrpA1^UAS.(B).cKa

(Sun et al., 2018)

abnormal locomotor behavior | adult stage | heat sensitive, with Scer\GAL4^GMR35B12, TrpA1^UAS.(B).cKa

(Sun et al., 2018)

abnormal locomotor behavior | adult stage | heat sensitive, with shi^1.UAS

(Riemensperger et al., 2013)

abnormal medium-term memory | adult stage, with Argk1^GD10436

(Bozzato et al., 2020)

abnormal memory, with 2mit^{dsRNA.UAS.cBa}

(Baggio et al., 2013)

abnormal memory, with brp^dsRNA.B.UAS, brp^dsRNA.C.UAS

(Knapek et al., 2011)

abnormal memory, with CaMKII^dsRNA.UAS

(Malik et al., 2013)

abnormal memory, with HDAC4^{UAS.hs.Tag:FLAG}, Scer\GAL80^ts.αTub84B

(Fitzsimons et al., 2013)

abnormal memory, with nemy^GD1646

(Iliadi et al., 2008)

abnormal memory, with neur^UAS.cPa

(Pavlopoulos et al., 2008)

abnormal memory, with neur^{ΔRING.UAS.EGFP}

(Pavlopoulos et al., 2008)

abnormal memory, with pain^dsRNA.UAS

(Sakai et al., 2012)

abnormal memory, with Phm^GD506

(Iliadi et al., 2008)

abnormal memory, with scrib^KK106065

(Cervantes-Sandoval et al., 2016)

abnormal memory, with teq^dsRNA.UAS

(Didelot et al., 2006)

abnormal memory | adult stage, with Ank2^KK104937

(Iqbal et al., 2013)

abnormal memory | adult stage, with Ctet\tetX^TNT-LC.UAS

(Galili et al., 2014)

abnormal memory | adult stage, with Dop2R^dsRNA.UAS

(Scholz-Kornehl and Schwärzel, 2016)

abnormal memory | adult stage, with Ecol\lexA^GMR44E04, Scer\GAL80^{IVS.WPRE.8xlexAop}, mAChR-A^JF02725

(Bielopolski et al., 2019)

abnormal memory | adult stage, with Hsap\MAPT^{UAS.2N4R.cSMa}

(Sheik Mohideen et al., 2015)

abnormal memory | adult stage, with Inx5^KK103391

(Liu et al., 2016)

abnormal memory | adult stage, with Inx6^GD3692

(Liu et al., 2016)

abnormal memory | adult stage, with KCNQ^JF02562

(Cavaliere et al., 2013)

abnormal memory | adult stage, with mAChR-A^JF02725

(Bielopolski et al., 2019)

abnormal memory | adult stage, with Rgk1^{dsRNA.shRNA.UAS}

(Murakami et al., 2017)

abnormal memory | adult stage, with tau^dsRNA.UAS

(Papanikolopoulou et al., 2019)

abnormal memory | adult stage, with zpg^GD2338

(Liu et al., 2016)

abnormal memory | adult stage | conditional, with Npha\HR^{eNpHR2.0.UAS.cBa.YFP}

(Liu et al., 2016)

abnormal memory | adult stage | heat sensitive, with Scer\GAL4^c205, shi^1.UAS

(Zhang et al., 2013)

abnormal memory | adult stage | heat sensitive, with shi^1.UAS

(Kirkhart and Scott, 2015, Vogt et al., 2014, Zhang et al., 2013)

abnormal memory | conditional, with meng^{MI03008-GFSTF.1}, slmb^UAS.vhhGFP4

(Lee et al., 2018)

abnormal memory | heat sensitive, with shi^1.UAS

(Schwaerzel et al., 2003, McGuire et al., 2001)

abnormal neuroanatomy, with FoxP^GD4320

(Castells-Nobau et al., 2019)

abnormal neuroanatomy, with FoxP^UASp.I1

(Castells-Nobau et al., 2019)

abnormal neuroanatomy, with FoxP^UASp.I2

(Castells-Nobau et al., 2019)

abnormal neuroanatomy, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

abnormal neuroanatomy, with Ten-m^GD3620

(Mosca et al., 2012)

abnormal neuroanatomy | adult stage, with Hr51^miRNA.UAS.a

(Lin et al., 2009)

abnormal neuroanatomy | adult stage, with tap^UAS.GFP

(Yuan et al., 2016)

abnormal neuroanatomy | larval stage, with myo^KK102411

(Yu et al., 2013, Yu et al., 2013)

abnormal neuroanatomy | larval stage, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

abnormal neuroanatomy | larval stage, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

abnormal pain response | adult stage, with tau^dsRNA.UAS

(Papanikolopoulou et al., 2019)

abnormal short-term memory | adult stage, with CG4266^GD11266

(Fliedner et al., 2020)

abnormal short-term memory | adult stage, with CG4266^HMC04041

(Fliedner et al., 2020)

abnormal size, with FoxP^GD4320

(Castells-Nobau et al., 2019)

abnormal size, with FoxP^UASp.I1

(Castells-Nobau et al., 2019)

abnormal size, with FoxP^UASp.I2

(Castells-Nobau et al., 2019)

abnormal smell perception | adult stage, with Prps^GL00463

(Brown et al., 2019)

abnormal smell perception | heat sensitive, with Scer\GAL4^Tab2-201Y, shi^1.UAS

(Kaun et al., 2011)

abnormal temperature response | adult stage, with Cyp6a17^{dsRNA.UAS.WIZ}

(Kang et al., 2011)

abnormal temperature response | adult stage, with Mmus\Prkaca^mC.UAS

(Kang et al., 2011)

abnormal thermotaxis, with Ctet\tetX^TNT-LC.UAS

(Hong et al., 2008)

abnormal thermotaxis, with Ctet\tetX^TNT-LC.UAS, Scer\GAL80^ts.αTub84B

(Hong et al., 2008)

abnormal thermotaxis | adult stage, with Ctet\tetX^TNT-LC.UAS

(Galili et al., 2014)

bang sensitive, with kcc^HMS01058

(Rusan et al., 2014)

chemical resistant | adult stage, with DopEcR^JF03415

(Aranda et al., 2017)

lethal, with Hsap\KCNJ2^UAS.EGFP

(Hong et al., 2008)

lethal, with pum^UAS.cSa

(Chen et al., 2008)

lethal - all die before end of pupal stage, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

lethal - all die before end of pupal stage, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

paralytic, with kcc^HMS01058

(Rusan et al., 2014)

short lived, with Cisd2^UAS.cCa

(Chen et al., 2020)

some die during pupal stage, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

some die during pupal stage, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

Phenotype Manifest In

adult mushroom body, with sgg^UAS.cBa

(Acebes et al., 2012)

adult mushroom body alpha-lobe, with FoxP^GD4320

(Castells-Nobau et al., 2019)

adult mushroom body alpha-lobe, with FoxP^UASp.I1

(Castells-Nobau et al., 2019)

adult mushroom body alpha-lobe, with FoxP^UASp.I2

(Castells-Nobau et al., 2019)

adult mushroom body beta-lobe | adult stage, with tap^UAS.GFP

(Yuan et al., 2016)

adult mushroom body gamma-lobe | adult stage, with Hr51^miRNA.UAS.a

(Lin et al., 2009)

embryonic/larval neuromuscular junction | larval stage, with myo^KK102411

(Yu et al., 2013, Yu et al., 2013)

embryonic heart cardioblast, with fra^GD14401

(Raza and Jacobs, 2016)

embryonic heart cardioblast, with robo1^dsRNA.UAS

(Raza and Jacobs, 2016)

embryonic heart cardioblast, with robo2^dsRNA.UAS

(Raza and Jacobs, 2016)

embryonic heart cardioblast, with sli^GD5822

(Raza and Jacobs, 2016)

filopodium | embryonic stage, with fra^GD14401

(Raza and Jacobs, 2016)

filopodium | embryonic stage, with robo1^dsRNA.UAS

(Raza and Jacobs, 2016)

filopodium | embryonic stage, with robo2^dsRNA.UAS

(Raza and Jacobs, 2016)

filopodium | embryonic stage, with sli^GD5822

(Raza and Jacobs, 2016)

flight muscle cell, with P32^HMS01059

(Liu et al., 2020)

flight muscle cell | adult stage, with Cisd2^{dsRNA.UAS.cUa}

(Chen et al., 2020)

flight muscle cell | adult stage, with Cisd2^miRNA.UAS

(Chen et al., 2020)

flight muscle cell | adult stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

flight muscle cell | adult stage, with Cisd2^{ΔCDGSH.UAS.Tag:HA}

(Chen et al., 2020)

flight muscle cell | adult stage, with Drp1^UAS.cUa

(Chen et al., 2020)

flight muscle cell | adult stage, with Marf^UAS.cUa

(Chen et al., 2020)

flight muscle cell | adult stage, with mge^HMC04737

(Chen et al., 2020)

flight muscle cell | adult stage, with Rab32^UASp.YFP

(Chen et al., 2020)

flight muscle cell | adult stage, with Tom70^HMC05662

(Chen et al., 2020)

flight muscle cell | adult stage, with tomboy40^JF03252

(Chen et al., 2020)

flight muscle cell | larval stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

intrinsic neuron, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

lamellipodium | embryonic stage, with fra^GD14401

(Raza and Jacobs, 2016)

lamellipodium | embryonic stage, with robo1^dsRNA.UAS

(Raza and Jacobs, 2016)

lamellipodium | embryonic stage, with robo2^dsRNA.UAS

(Raza and Jacobs, 2016)

lamellipodium | embryonic stage, with sli^GD5822

(Raza and Jacobs, 2016)

larval transverse nerve, with myo^KK102411

(Yu et al., 2013)

mitochondrion | adult stage, with Cisd2^{dsRNA.UAS.cUa}

(Chen et al., 2020)

mitochondrion | adult stage, with Cisd2^miRNA.UAS

(Chen et al., 2020)

mitochondrion | adult stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

mitochondrion | adult stage, with Cisd2^{ΔCDGSH.UAS.Tag:HA}

(Chen et al., 2020)

mitochondrion | adult stage, with Drp1^UAS.cUa

(Chen et al., 2020)

mitochondrion | adult stage, with Marf^UAS.cUa

(Chen et al., 2020)

mitochondrion | adult stage, with mge^HMC04737

(Chen et al., 2020)

mitochondrion | adult stage, with P32^HMS01059

(Liu et al., 2020)

mitochondrion | adult stage, with Rab32^UASp.YFP

(Chen et al., 2020)

mitochondrion | adult stage, with Tom70^HMC05662

(Chen et al., 2020)

mitochondrion | adult stage, with tomboy40^JF03252

(Chen et al., 2020)

mitochondrion | larval stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

myotube | third instar larval stage, with Hsap\TMEM258^UAS.CFP

(Ding et al., 2017)

myotube | third instar larval stage, with klar^{KASH.UAS.Tag:HA}

(Ding et al., 2017)

myotube | third instar larval stage, with kud^KO, kud^dsRNA.UAS

(Ding et al., 2017)

myotube | third instar larval stage, with kud^UAS.CFP

(Ding et al., 2017)

NMJ bouton, with Ten-m^GD3620

(Mosca et al., 2012)

nucleus | third instar larval stage, with Hsap\TMEM258^UAS.CFP

(Ding et al., 2017)

nucleus | third instar larval stage, with klar^{KASH.UAS.Tag:HA}

(Ding et al., 2017)

nucleus | third instar larval stage, with kud^KO, kud^dsRNA.UAS

(Ding et al., 2017)

nucleus | third instar larval stage, with kud^UAS.CFP

(Ding et al., 2017)

synapse, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

terminal bouton, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

terminal bouton, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

type I bouton | ectopic, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

type I bouton | ectopic, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

type Ib terminal bouton | ectopic, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

type Ib terminal bouton | ectopic, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

type Is terminal bouton, with Tip60^dsRNA.Z.UAS

(Sarthi and Elefant, 2011)

type Is terminal bouton, with Tip60^E431Q.UAS

(Sarthi and Elefant, 2011)

vesicle | adult stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

vesicle | larval stage, with Cisd2^UAS.cCa

(Chen et al., 2020)

Detailed Description

Statement

Reference

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^Mef2.247 cells in adults does not affect startle-induced climbing behavior, compared to controls.

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 32[o]C) of Scer\GAL4^Mef2.247 cells in adults does not affect startle-induced climbing behavior, compared to controls; thermogenetic activation of the combined set of Scer\GAL4^GMR16A06 and Scer\GAL4^Mef2.247 cells, or the combined set of Scer\GAL4^GMR35B12 and Scer\GAL4^Mef2.247 cells, in adults significantly reduces startle-induced climbing behavior, compared to controls, but in both cases this phenotype is significantly less severe than activation without Scer\GAL4^Mef2.247.

(Sun et al., 2018)

Optogenetic stimulation (using Npha\HR^{e.UAS.cBa.YFP} with 593 nm (yellow) light activation) of Scer\GAL4^Mef2.247 neurons significantly impairs visual short term memory following training with pain stimulus in adult flies, compared to controls.

Blocking the output (using shi^ts.UAS.cUaat 30[o]C) of Scer\GAL4^Mef2.247 neurons does not affect visual short term memory following training with pain stimulus in adult flies, compared to controls.

(Liu et al., 2016)

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^Mef2.247 cells in adults significantly reduces 5 min (single-trial conditioned) and 30 min (multiple-trial conditioned) aversive taste memory, compared to controls.

(Kirkhart and Scott, 2015)

Inhibition of neural activity in Scer\GAL4^Mef2.247-expressing neurons does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

(Shankar et al., 2015)

Inhibition (using shi^ts.UAS.cUa) of Scer\GAL4^Mef2.247 neurons does not affect the reduction in food intake observed when larvae are moved to essential amino acid-deficient food, compared to controls.

(Bjordal et al., 2014)

Inhibition (using Ctet\tetX^TNT-LC.UAS) of Scer\GAL4^Mef2.247 cells in adults significantly reduces temperature avoidance and aversive temperature olfactory memory, compared to controls.

(Galili et al., 2014)

Inhibition (using shi^1.UAS at 33[o]C) of Scer\GAL4^Mef2.247 cells in adults significantly reduces aversive and appetitive 1-min visual memory, compared to controls; inhibition during training or testing alone significantly reduces aversive and appetitive 30-min visual memory, compared to controls; inhibition does not significantly affect responses to sugar or electric shock, compared to controls.

(Vogt et al., 2014)

Inhibition (using shi^1.UAS at 31[o]C) of Scer\GAL4^Mef2.247 cells in adults significantly reduces short-term aversive olfactory, but not visual, unimodal memory, compared to controls; inhibition significantly reduces short-term aversive memory for tested olfactory cues that are associated with conditioned visual cues, compared to controls, with no effect on short-term aversive memory for tested visual cues that are associated with conditioned olfactory cues.

Inhibition (using shi^1.UAS at 31[o]C) of the combined set of Scer\GAL4^Mef2.247 cells and Scer\GAL4^c205 cells in adults significantly reduces short-term aversive memory for tested visual cues that are associated with conditioned olfactory cues, and for tested olfactory cues that are associated with conditioned visual cues, compared to controls.

(Zhang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^Mef2.247/Dop1R1^f02676 is a non-enhancer of abnormal memory | adult stage | heat sensitive phenotype of Ecol\lexA^GMR58E02, TrpA1^{13xlexAop.JFRC26}

(Liu et al., 2012)

Suppressor of

Statement

Reference

Scer\GAL4^Mef2.247, orb2^UAS.B.cKa, Scer\GAL80^ts.αTub84B is a suppressor of abnormal learning | adult stage phenotype of orb2::Mmus\Cpeb2^RBD.GFP

(Krüttner et al., 2012)

Scer\GAL4^Mef2.247, orb2^UAS.B.cKa, Scer\GAL80^ts.αTub84B is a suppressor of abnormal courtship behavior | adult stage phenotype of orb2::Mmus\Cpeb2^RBD.GFP

(Krüttner et al., 2012)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, Ctet\tetX^UAS.cTa is a suppressor | partially of paralytic | recessive phenotype of kcc^DHS1

(Hekmat-Scafe et al., 2010)

Ctet\tetX^TNT-LC.UAS/Scer\GAL4^Mef2.247 is a suppressor | partially of paralytic | recessive phenotype of kcc^DHS1

(Hekmat-Scafe et al., 2010)

dlg1^WT.UAS.EGFP/Scer\GAL4^Mef2.247 is a suppressor of abnormal neuroanatomy phenotype of slo¹

(Lee and Wu, 2010)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Mef2.247/P32^HMS01059 is a non-suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Chchd2^8-8

(Liu et al., 2020)

Scer\GAL4^Mef2.247/fra^UAS.cKa is a non-suppressor of abnormal cell migration | dominant | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a non-suppressor of abnormal cell migration | dominant | embryonic stage phenotype of robo1¹, robo2^lea-2

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a non-suppressor of abnormal cell migration | dominant | embryonic stage phenotype of fra³

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247, Scer\GAL80^ts.αTub84B, orb2^RBD.UAS.B is a non-suppressor of abnormal learning | adult stage phenotype of orb2::Mmus\Cpeb2^RBD.GFP

(Krüttner et al., 2012)

Scer\GAL4^Mef2.247, Scer\GAL80^ts.αTub84B, orb2^RBD.UAS.B is a non-suppressor of abnormal courtship behavior | adult stage phenotype of orb2::Mmus\Cpeb2^RBD.GFP

(Krüttner et al., 2012)

Scer\GAL4^Mef2.247/Dop1R1^f02676 is a non-suppressor of abnormal memory | adult stage | heat sensitive phenotype of Ecol\lexA^GMR58E02, TrpA1^{13xlexAop.JFRC26}

(Liu et al., 2012)

Mmus\Nbea^UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of rg^γ5

(Volders et al., 2012)

Mmus\Nbea^UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of rg^FDD

(Volders et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, enhanceable by Rab32^UASp.YFP, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has vesicle | adult stage phenotype, enhanceable by Rab32^UASp.YFP, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, enhanceable by Rab32^{Q79L.UASp.YFP}, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, enhanceable by Rab32^{Q79L.UASp.YFP}, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has vesicle | adult stage phenotype, enhanceable by Rab32^{Q79L.UASp.YFP}, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, enhanceable by Marf^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, enhanceable by Marf^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, enhanceable by Rab32^UASp.YFP, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Scer\GAL4^Mef2.247, kud^UAS.CFP has nucleus | third instar larval stage phenotype, enhanceable by klar^Δ1-18/klar[+]

(Ding et al., 2017)

Scer\GAL4^Mef2.247, kud^UAS.CFP has myotube | third instar larval stage phenotype, enhanceable by klar^Δ1-18/klar[+]

(Ding et al., 2017)

Scer\GAL4^Mef2.247, kud^UAS.CFP has nucleus | third instar larval stage phenotype, enhanceable by koi[+]/koi⁸⁰

(Ding et al., 2017)

Scer\GAL4^Mef2.247, kud^UAS.CFP has myotube | third instar larval stage phenotype, enhanceable by koi[+]/koi⁸⁰

(Ding et al., 2017)

Hsap\TMEM258^UAS.CFP, Scer\GAL4^Mef2.247 has nucleus | third instar larval stage phenotype, enhanceable by klar^Δ1-18/klar[+]

(Ding et al., 2017)

Hsap\TMEM258^UAS.CFP, Scer\GAL4^Mef2.247 has myotube | third instar larval stage phenotype, enhanceable by klar^Δ1-18/klar[+]

(Ding et al., 2017)

Suppressed by

Statement

Reference

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, suppressible by Rab32¹/Rab32¹

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, suppressible by Rab32¹/Rab32¹

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has vesicle | adult stage phenotype, suppressible by Rab32¹/Rab32¹

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, suppressible by Rab32^{T33N.UASp.YFP}, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, suppressible by Rab32^{T33N.UASp.YFP}, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has vesicle | adult stage phenotype, suppressible by Rab32^{T33N.UASp.YFP}, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, suppressible | partially by Drp1^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, suppressible | partially by Drp1^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

NOT suppressed by

Statement

Reference

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has flight muscle cell | adult stage phenotype, non-suppressible by Marf^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has mitochondrion | adult stage phenotype, non-suppressible by Marf^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd2^UAS.cCa, Scer\GAL4^Mef2.247 has vesicle | adult stage phenotype, non-suppressible by Marf^UAS.cUa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Enhancer of

Statement

Reference

Rab32^UASp.YFP, Scer\GAL4^Mef2.247 is an enhancer of flight muscle cell | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^UASp.YFP, Scer\GAL4^Mef2.247 is an enhancer of mitochondrion | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^UASp.YFP, Scer\GAL4^Mef2.247 is an enhancer of vesicle | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^{Q79L.UASp.YFP}, Scer\GAL4^Mef2.247 is an enhancer of flight muscle cell | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^{Q79L.UASp.YFP}, Scer\GAL4^Mef2.247 is an enhancer of mitochondrion | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^{Q79L.UASp.YFP}, Scer\GAL4^Mef2.247 is an enhancer of vesicle | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is an enhancer of flight muscle cell | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is an enhancer of mitochondrion | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Scer\GAL4^Mef2.247/kud^UAS.CFP is an enhancer of nucleus | third instar larval stage phenotype of koi⁸⁰

(Ding et al., 2017)

Scer\GAL4^Mef2.247/kud^UAS.CFP is an enhancer of myotube | third instar larval stage phenotype of koi⁸⁰

(Ding et al., 2017)

Suppressor of

Statement

Reference

Cisd2^UAS.cCa/Scer\GAL4^Mef2.247 is a suppressor of flight muscle cell | adult stage phenotype of Rab32¹

(Chen et al., 2020)

Cisd2^UAS.cCa/Scer\GAL4^Mef2.247 is a suppressor of mitochondrion | adult stage phenotype of Rab32¹

(Chen et al., 2020)

Scer\GAL4^Mef2.247/Mmus\Cisd1::Mmus\Cisd2^UAS.Tag:HA is a suppressor | partially of mitochondrion | adult stage phenotype of Cisd2^2-1

(Chen et al., 2020)

Scer\GAL4^Mef2.247/Mmus\Cisd1::Mmus\Cisd2^UAS.Tag:HA is a suppressor | partially of flight muscle cell | adult stage phenotype of Cisd2^2-1

(Chen et al., 2020)

Rab32^{T33N.UASp.YFP}, Scer\GAL4^Mef2.247 is a suppressor of flight muscle cell | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^{T33N.UASp.YFP}, Scer\GAL4^Mef2.247 is a suppressor of mitochondrion | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Rab32^{T33N.UASp.YFP}, Scer\GAL4^Mef2.247 is a suppressor of vesicle | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Drp1^UAS.cUa, Scer\GAL4^Mef2.247 is a suppressor | partially of flight muscle cell | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Drp1^UAS.cUa, Scer\GAL4^Mef2.247 is a suppressor | partially of mitochondrion | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Scer\GAL4^Mef2.247/P32^HMS01059 is a suppressor of mitochondrion | adult stage phenotype of Chchd2^8-8

(Liu et al., 2020)

Scer\GAL4^Mef2.247/P32^HMS01059 is a suppressor of flight muscle cell phenotype of Chchd2^8-8

(Liu et al., 2020)

Scer\GAL4^Mef2.247/fra^UAS.cKa is a suppressor | partially of lamellipodium | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/fra^UAS.cKa is a suppressor | partially of filopodium | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a suppressor | partially of embryonic heart cardioblast phenotype of robo1¹, robo2^lea-2

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a suppressor | partially of lamellipodium | embryonic stage phenotype of robo1¹, robo2^lea-2

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/fra^UAS.cKa is a suppressor | partially of embryonic heart cardioblast phenotype of robo2^lea-2

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a suppressor | partially of embryonic heart cardioblast phenotype of fra³

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a suppressor | partially of lamellipodium | embryonic stage phenotype of fra³

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a suppressor | partially of filopodium | embryonic stage phenotype of fra³

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a suppressor | partially of heart primordium phenotype of fra³

(Raza and Jacobs, 2016)

dlg1^WT.UAS.EGFP/Scer\GAL4^Mef2.247 is a suppressor of NMJ bouton | increased number phenotype of slo¹

(Lee and Wu, 2010)

dlg1^WT.UAS.EGFP/Scer\GAL4^Mef2.247 is a suppressor of neuromuscular junction phenotype of slo¹

(Lee and Wu, 2010)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Mef2.247/Mmus\Cisd1^UAS.Tag:HA is a non-suppressor of flight muscle cell | adult stage phenotype of Cisd2^2-1

(Chen et al., 2020)

Scer\GAL4^Mef2.247/Mmus\Cisd1^UAS.Tag:HA is a non-suppressor of mitochondrion | adult stage phenotype of Cisd2^2-1

(Chen et al., 2020)

Mmus\Cisd2^UAS.Tag:HA/Scer\GAL4^Mef2.247 is a non-suppressor of flight muscle cell | adult stage phenotype of Cisd2^2-1

(Chen et al., 2020)

Mmus\Cisd2^UAS.Tag:HA/Scer\GAL4^Mef2.247 is a non-suppressor of mitochondrion | adult stage phenotype of Cisd2^2-1

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is a non-suppressor of flight muscle cell | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is a non-suppressor of mitochondrion | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is a non-suppressor of vesicle | adult stage phenotype of Cisd2^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Scer\GAL4^Mef2.247/P32^HMS01059 is a non-suppressor of rhabdomere | adult stage phenotype of Chchd2^8-8

(Liu et al., 2020)

Scer\GAL4^Mef2.247/fra^UAS.cKa is a non-suppressor of heart primordium phenotype of robo1¹

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a non-suppressor of filopodium | embryonic stage phenotype of robo1¹, robo2^lea-2

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa is a non-suppressor of heart primordium phenotype of robo1¹, robo2^lea-2

(Raza and Jacobs, 2016)

Mmus\Nbea^UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of adult mushroom body phenotype of rg^γ5

(Volders et al., 2012)

Mmus\Nbea^UAS.cVa/Scer\GAL4^Mef2.247 is a non-suppressor of adult mushroom body phenotype of rg^FDD

(Volders et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Mef2.247/uex^UAS.cWa rescues uex^MI01943

(Wu et al., 2020)

Scer\GAL4^Mef2.247/DopEcR^UAS.cAa rescues DopEcR^c02142

(Aranda et al., 2017)

Scer\GAL4^Mef2.247/fra^UAS.cKa rescues fra³

(Raza and Jacobs, 2016)

unc-5^{UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^Mef2.247 rescues unc-5⁸

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/Dop2R^UAS.cSa rescues Dop2R^Δ1

(Scholz-Kornehl and Schwärzel, 2016)

Scer\GAL4^Mef2.247/Dop1R1^UAS.cLa rescues Dop1R1^f02676

(Ichinose et al., 2015)

Scer\GAL4^Mef2.247/Drep2^UAS.cAa rescues Drep2^ex13

(Andlauer et al., 2014)

KCNQ^UAS.cOa/Scer\GAL4^Mef2.247 rescues KCNQ¹⁸⁶

(Cavaliere et al., 2013)

Scer\GAL4^Mef2.247/Fmr1^UAS.cWa rescues Fmr1³

(Kanellopoulos et al., 2012)

Scer\GAL4^Mef2.247/Dop1R1^f02676 rescues Dop1R1^f02676

(Liu et al., 2012)

Scer\GAL4^Mef2.247, pain^EP2451 rescues pain^EP2451

(Sakai et al., 2012)

Scer\GAL4^Mef2.247/rut^UAS.cZa rescues rut¹

(Scheunemann et al., 2012)

Scer\GAL4^GH298, dnc^UAS.cCa, Scer\GAL4^Mef2.247 rescues dnc¹

(Scheunemann et al., 2012)

Scer\GAL4^Mef2.247/Dop1R1^UAS.cBa rescues Dop1R1^PL00420

(Bang et al., 2011)

Scer\GAL4^Mef2.247/Dop1R1^UAS.cBa rescues Df(3R)red-P52/+

(Bang et al., 2011)

Scer\GAL4^Mef2.247/Cyp6a17^UAS.cKa rescues Cyp6a17^Δ173

(Kang et al., 2011)

Scer\GAL4^Mef2.247/Syn^1-12.UAS rescues Syn⁹⁷

(Michels et al., 2011)

Su(H)^UAS.cPa/Scer\GAL4^Mef2.247 rescues Su(H)⁸

(Song et al., 2009)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, orb2^A.UAS rescues orb2^ΔQ/orb2^Δ

(Keleman et al., 2007)

Scer\GAL4^Mef2.247, orb2^B.UAS, Scer\GAL4^Mef2.247 rescues orb2^ΔQ/orb2^Δ

(Keleman et al., 2007)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, Dop1R1^f02676 rescues Dop1R1^f02676

(Kim et al., 2007)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, Dop1R1^f02676 rescues In(3LR)234/Dop1R1^f02676

(Kim et al., 2007)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, rut^UAS.cZa rescues rut²⁰⁸⁰

(Zars et al., 2000)

Partially rescues

Scer\GAL4^Mef2.247/Pen^UASp.cGa partially rescues Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^Mef2.247/mAChR-A^UAS.Tag:FLAG partially rescues mAChR-A^MI13848

(Bielopolski et al., 2019)

Scer\GAL4^Mef2.247, Prosap^UAS.Tag:MYC, Scer\GAL4^GH146 partially rescues Prosap^8k

(Wu et al., 2017)

Scer\GAL4^Mef2.247/sli^UAS.cUa partially rescues sli²

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/robo1^UAS.cKa partially rescues robo1¹

(Raza and Jacobs, 2016)

Scer\GAL4^Mef2.247/Dop1R1^f02676 partially rescues Dop1R1^f02676

(Vogt et al., 2014)

dnc^UAS.cCa, Scer\GAL4^Mef2.247, Scer\GAL4^NP1227 partially rescues dnc¹

(Scheunemann et al., 2012)

Scer\GAL4^Mef2.247/rg^UAS.cVa partially rescues rg^γ5

(Volders et al., 2012)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, kcc^UAS.cHb partially rescues kcc^DHS1

(Hekmat-Scafe et al., 2010)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, RanBPM^S.UAS partially rescues RanBPM^k05201

(Scantlebury et al., 2010)

Scer\GAL4^Mef2.247, RanBPM^long.UAS, Scer\GAL4^Mef2.247 partially rescues RanBPM^k05201

(Scantlebury et al., 2010)

Scer\GAL4^Mef2.247/gish^UAS.cTa partially rescues gish^MB896

(Tan et al., 2010)

Scer\GAL4^Mef2.247/Pka-C1^UAS.cKa partially rescues Pka-C1^X4/Pka-C1^MB581

(Hong et al., 2008)

rut^UAS.cHa/Scer\GAL4^Mef2.247 partially rescues rut¹

(Hong et al., 2008)

Nrg^167.UAS/Scer\GAL4^Mef2.247 partially rescues Nrg^ibx

(Carhan et al., 2005)

Nrg^180.I.UAS/Scer\GAL4^Mef2.247 partially rescues Nrg^ibx

(Carhan et al., 2005)

Scer\GAL4^Mef2.247, Scer\GAL4^Mef2.247, rut^UAS.cZa partially rescues rut²⁰⁸⁰

(Schwaerzel et al., 2003)

Fails to rescue

Scer\GAL4^Mef2.247/Prosap^UAS.Tag:MYC fails to rescue Prosap^8k

(Wu et al., 2017)

Scer\GAL4^Mef2.247/plum^UAS.Tag:HA fails to rescue plum^Δ2

(Yu et al., 2013)

Scer\GAL4^Mef2.247/Ten-a^UAS.cHa fails to rescue Df(1)Ten-a

(Mosca et al., 2012)

Scer\GAL4^Mef2.247, inc^f00285 fails to rescue inc^f00285

(Pfeiffenberger and Allada, 2012)

dnc^UAS.cCa/Scer\GAL4^Mef2.247 fails to rescue dnc¹

(Scheunemann et al., 2012)

Scer\GAL4^Mef2.247/rg^UAS.cVa fails to rescue rg^FDD

(Volders et al., 2012)

Scer\GAL4^Mef2.247, Nf1^UAS.cWa, Scer\GAL80^ts.αTub84B fails to rescue Nf1^E1/Nf1^E2

(Gouzi et al., 2011)

Comments

Expression of Su(H)^Scer\UAS.cPa under the control of Scer\GAL4^Mef2.247 (using the temperature sensitive Scer\GAL80^ts.αTub84B allele to limit expression to the adult stage) rescues the reduced 24 hour memory phenotype seen in Su(H)⁸ homozygotes.

(Song et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

50742

w^*; P{Mef2-GAL4.247}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4²⁴⁷

Scer\GAL4^Mef2.247

Name Synonyms

Secondary FlyBase IDs

FBal0155903
FBal0117652
FBal0213103

References (185)

Report Sections

Open Close