Drives expression in the whole of the alpha and beta lobes, with stronger expression being detected in the surface and posterior subdivisions. In the gamma lobe, the main body of the lobe stains stronger than the dorsomedial tip.
Stains a large set of embryonic- and larval-born gamma neurons as well as glial cells in the ventral nerve cord.
Expression of Scer\GAL4Mef2.247 is stronger in the alpha/beta and gamma mushroom body lobes than in the alpha'/beta' mushroom body lobes.
Expression is limited to alpha, beta, and gamma neurons in the adult mushroom body.
In the mushroom body, Scer\GAL4Mef2.247 drives expression in the whole of the alpha and beta lobes, with stronger expression being detected in the surface and posterior subdivisions. In the gamma lobe, the main body of the lobe stains stronger than the dorsomedial tip.
Expression is found in only a few alpha'/beta' neurons.
Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4Mef2.247 cells in adults does not affect startle-induced climbing behavior, compared to controls.
Thermogenetic activation (using TrpA1UAS.(B).cKa at 32[o]C) of Scer\GAL4Mef2.247 cells in adults does not affect startle-induced climbing behavior, compared to controls; thermogenetic activation of the combined set of Scer\GAL4GMR16A06 and Scer\GAL4Mef2.247 cells, or the combined set of Scer\GAL4GMR35B12 and Scer\GAL4Mef2.247 cells, in adults significantly reduces startle-induced climbing behavior, compared to controls, but in both cases this phenotype is significantly less severe than activation without Scer\GAL4Mef2.247.
Optogenetic stimulation (using Npha\HRe.UAS.cBa.YFP with 593 nm (yellow) light activation) of Scer\GAL4Mef2.247 neurons significantly impairs visual short term memory following training with pain stimulus in adult flies, compared to controls.
Blocking the output (using shits.UAS.cUaat 30[o]C) of Scer\GAL4Mef2.247 neurons does not affect visual short term memory following training with pain stimulus in adult flies, compared to controls.
Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4Mef2.247 cells in adults significantly reduces 5 min (single-trial conditioned) and 30 min (multiple-trial conditioned) aversive taste memory, compared to controls.
Inhibition of neural activity in Scer\GAL4Mef2.247-expressing neurons does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.
Inhibition (using shits.UAS.cUa) of Scer\GAL4Mef2.247 neurons does not affect the reduction in food intake observed when larvae are moved to essential amino acid-deficient food, compared to controls.
Inhibition (using Ctet\tetXTNT-LC.UAS) of Scer\GAL4Mef2.247 cells in adults significantly reduces temperature avoidance and aversive temperature olfactory memory, compared to controls.
Inhibition (using shi1.UAS at 33[o]C) of Scer\GAL4Mef2.247 cells in adults significantly reduces aversive and appetitive 1-min visual memory, compared to controls; inhibition during training or testing alone significantly reduces aversive and appetitive 30-min visual memory, compared to controls; inhibition does not significantly affect responses to sugar or electric shock, compared to controls.
Inhibition (using shi1.UAS at 31[o]C) of Scer\GAL4Mef2.247 cells in adults significantly reduces short-term aversive olfactory, but not visual, unimodal memory, compared to controls; inhibition significantly reduces short-term aversive memory for tested olfactory cues that are associated with conditioned visual cues, compared to controls, with no effect on short-term aversive memory for tested visual cues that are associated with conditioned olfactory cues.
Inhibition (using shi1.UAS at 31[o]C) of the combined set of Scer\GAL4Mef2.247 cells and Scer\GAL4c205 cells in adults significantly reduces short-term aversive memory for tested visual cues that are associated with conditioned olfactory cues, and for tested olfactory cues that are associated with conditioned visual cues, compared to controls.
Scer\GAL4Mef2.247/Dop1R1f02676 is a non-enhancer of memory defective | adult stage | heat sensitive phenotype of Ecol\lexAGMR58E02, TrpA113xlexAop.JFRC26
Scer\GAL4Mef2.247, orb2UAS.B.cKa, Scer\GAL80ts.αTub84B is a suppressor of learning defective | adult stage phenotype of orb2::Mmus\Cpeb2RBD.GFP
Scer\GAL4Mef2.247, orb2UAS.B.cKa, Scer\GAL80ts.αTub84B is a suppressor of courtship behavior defective | adult stage phenotype of orb2::Mmus\Cpeb2RBD.GFP
Scer\GAL4Mef2.247, Scer\GAL4Mef2.247, Ctet\tetXUAS.cTa is a suppressor | partially of paralytic | recessive phenotype of kccDHS1
Ctet\tetXTNT-LC.UAS/Scer\GAL4Mef2.247 is a suppressor | partially of paralytic | recessive phenotype of kccDHS1
dlg1WT.UAS.EGFP/Scer\GAL4Mef2.247 is a suppressor of neuroanatomy defective phenotype of slo1
Scer\GAL4Mef2.247/fraUAS.cKa is a non-suppressor of cell migration defective | dominant | embryonic stage phenotype of robo11
Scer\GAL4Mef2.247/robo1UAS.cKa is a non-suppressor of cell migration defective | dominant | embryonic stage phenotype of robo11, robo2lea-2
Scer\GAL4Mef2.247/robo1UAS.cKa is a non-suppressor of cell migration defective | dominant | embryonic stage phenotype of fra3
Scer\GAL4Mef2.247, Scer\GAL80ts.αTub84B, orb2RBD.UAS.B is a non-suppressor of learning defective | adult stage phenotype of orb2::Mmus\Cpeb2RBD.GFP
Scer\GAL4Mef2.247, Scer\GAL80ts.αTub84B, orb2RBD.UAS.B is a non-suppressor of courtship behavior defective | adult stage phenotype of orb2::Mmus\Cpeb2RBD.GFP
Scer\GAL4Mef2.247/Dop1R1f02676 is a non-suppressor of memory defective | adult stage | heat sensitive phenotype of Ecol\lexAGMR58E02, TrpA113xlexAop.JFRC26
Mmus\NbeaUAS.cVa/Scer\GAL4Mef2.247 is a non-suppressor of neuroanatomy defective | adult stage phenotype of rgγ5
Mmus\NbeaUAS.cVa/Scer\GAL4Mef2.247 is a non-suppressor of neuroanatomy defective | adult stage phenotype of rgFDD
Scer\GAL4Mef2.247, kudUAS.CFP has nucleus | third instar larval stage phenotype, enhanceable by klarΔ1-18/klar[+]
Scer\GAL4Mef2.247, kudUAS.CFP has myotube | third instar larval stage phenotype, enhanceable by klarΔ1-18/klar[+]
Scer\GAL4Mef2.247, kudUAS.CFP has nucleus | third instar larval stage phenotype, enhanceable by koi[+]/koi80
Scer\GAL4Mef2.247, kudUAS.CFP has myotube | third instar larval stage phenotype, enhanceable by koi[+]/koi80
Hsap\TMEM258UAS.CFP, Scer\GAL4Mef2.247 has nucleus | third instar larval stage phenotype, enhanceable by klarΔ1-18/klar[+]
Hsap\TMEM258UAS.CFP, Scer\GAL4Mef2.247 has myotube | third instar larval stage phenotype, enhanceable by klarΔ1-18/klar[+]
Scer\GAL4Mef2.247/kudUAS.CFP is an enhancer of nucleus | third instar larval stage phenotype of koi80
Scer\GAL4Mef2.247/kudUAS.CFP is an enhancer of myotube | third instar larval stage phenotype of koi80
Scer\GAL4Mef2.247/fraUAS.cKa is a suppressor | partially of lamellipodium | embryonic stage phenotype of robo11
Scer\GAL4Mef2.247/fraUAS.cKa is a suppressor | partially of filopodium | embryonic stage phenotype of robo11
Scer\GAL4Mef2.247/robo1UAS.cKa is a suppressor | partially of embryonic heart cardioblast phenotype of robo11, robo2lea-2
Scer\GAL4Mef2.247/robo1UAS.cKa is a suppressor | partially of lamellipodium | embryonic stage phenotype of robo11, robo2lea-2
Scer\GAL4Mef2.247/fraUAS.cKa is a suppressor | partially of embryonic heart cardioblast phenotype of robo2lea-2
Scer\GAL4Mef2.247/robo1UAS.cKa is a suppressor | partially of embryonic heart cardioblast phenotype of fra3
Scer\GAL4Mef2.247/robo1UAS.cKa is a suppressor | partially of lamellipodium | embryonic stage phenotype of fra3
Scer\GAL4Mef2.247/robo1UAS.cKa is a suppressor | partially of filopodium | embryonic stage phenotype of fra3
Scer\GAL4Mef2.247/robo1UAS.cKa is a suppressor | partially of heart primordium phenotype of fra3
dlg1WT.UAS.EGFP/Scer\GAL4Mef2.247 is a suppressor of NMJ bouton | supernumerary phenotype of slo1
dlg1WT.UAS.EGFP/Scer\GAL4Mef2.247 is a suppressor of neuromuscular junction phenotype of slo1
Scer\GAL4Mef2.247/fraUAS.cKa is a non-suppressor of heart primordium phenotype of robo11
Scer\GAL4Mef2.247/robo1UAS.cKa is a non-suppressor of filopodium | embryonic stage phenotype of robo11, robo2lea-2
Scer\GAL4Mef2.247/robo1UAS.cKa is a non-suppressor of heart primordium phenotype of robo11, robo2lea-2
Mmus\NbeaUAS.cVa/Scer\GAL4Mef2.247 is a non-suppressor of adult mushroom body phenotype of rgγ5
Mmus\NbeaUAS.cVa/Scer\GAL4Mef2.247 is a non-suppressor of adult mushroom body phenotype of rgFDD
Scer\GAL4Mef2.247/mAChR-AUAS.Tag:FLAG partially rescues mAChR-AMI13848
Scer\GAL4Mef2.247, ProsapUAS.Tag:MYC, Scer\GAL4GH146 partially rescues Prosap8k
Scer\GAL4Mef2.247/sliUAS.cUa partially rescues sli2
Scer\GAL4Mef2.247/robo1UAS.cKa partially rescues robo11
Scer\GAL4Mef2.247/Dop1R1f02676 partially rescues Dop1R1f02676
dncUAS.cCa, Scer\GAL4Mef2.247, Scer\GAL4NP1227 partially rescues dnc1
Scer\GAL4Mef2.247/rgUAS.cVa partially rescues rgγ5
Scer\GAL4Mef2.247, Scer\GAL4Mef2.247, kccUAS.cHb partially rescues kccDHS1
Scer\GAL4Mef2.247, Scer\GAL4Mef2.247, RanBPMS.UAS partially rescues RanBPMk05201
Scer\GAL4Mef2.247, RanBPMlong.UAS, Scer\GAL4Mef2.247 partially rescues RanBPMk05201
Scer\GAL4Mef2.247/gishUAS.cTa partially rescues gishMB896
Scer\GAL4Mef2.247/Pka-C1UAS.cKa partially rescues Pka-C1X4/Pka-C1MB581
rutUAS.cHa/Scer\GAL4Mef2.247 partially rescues rut1
Nrg167.UAS/Scer\GAL4Mef2.247 partially rescues Nrgibx
Nrg180.I.UAS/Scer\GAL4Mef2.247 partially rescues Nrgibx
Scer\GAL4Mef2.247, Scer\GAL4Mef2.247, rutUAS.cZa partially rescues rut2080
Scer\GAL4Mef2.247/ProsapUAS.Tag:MYC fails to rescue Prosap8k
Scer\GAL4Mef2.247/plumUAS.Tag:HA fails to rescue plumΔ2
Scer\GAL4Mef2.247/Ten-aUAS.cHa fails to rescue Df(1)Ten-a
Scer\GAL4Mef2.247, incf00285 fails to rescue incf00285
dncUAS.cCa/Scer\GAL4Mef2.247 fails to rescue dnc1
Scer\GAL4Mef2.247/rgUAS.cVa fails to rescue rgFDD
Scer\GAL4Mef2.247, Nf1UAS.cWa, Scer\GAL80ts.αTub84B fails to rescue Nf1E1/Nf1E2
Expression of Su(H)Scer\UAS.cPa under the control of Scer\GAL4Mef2.247 (using the temperature sensitive Scer\GAL80ts.αTub84B allele to limit expression to the adult stage) rescues the reduced 24 hour memory phenotype seen in Su(H)8 homozygotes.