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Allele Dmel\Dab²

General Information
Symbol	Dmel\Dab2	Species	D. melanogaster
Name		FlyBase ID	FBal0247453
Feature type	allele	Associated gene	Dmel\Dab
Allele class	hypomorphic allele - molecular evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - molecular evidence (Song et al., 2010)
Mutagen	P-element activity (Song et al., 2010)
Mutations Mapped to the Genome
Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype	P{XP}Dabd11255 (Song et al., 2010)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion, resulting in a 1887bp deletion which includes the 5' promoter region and the first exon (which includes the translation start site) of Dab. (Song et al., 2010) 1887bp deletion which begins 1695bp upstream of the Dab start codon and ends 192bp downstream of the start codon. (Song, 2010.11.22)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Song, 2010.11.22) fertile (with Dab1) (Song et al., 2010) lethal (Song, 2010.11.22) neuroanatomy defective | embryonic stage | maternal effect (with Dab1) (Song et al., 2010) viable (with Dab1) (Song et al., 2010)
Phenotype Manifest In
	embryo | dorsal closure stage | maternal effect (with Dab1) (Song et al., 2010) embryo | embryonic stage 5 | maternal effect (with Dab1) (Song et al., 2010) embryonic leading edge cell | maternal effect (with Dab1) (Song et al., 2010) intersegmental nerve branch ISNb of A1-7 | maternal effect (with Dab1) (Song et al., 2010) segmental nerve branch SNa of A1-7 | maternal effect (with Dab1) (Song et al., 2010)
Detailed Description
	Statement Reference ISNb motor axons stall and fail to innervate their most distal target (muscle 12) in 46% of hemisegments in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab). These embryos show a "stop short" phenotype in the dorsal branch of the SNa motor nerve, with the axons stopping short and failing to reach their muscle target in 39% of hemisegments. ISNb motor axons stall and fail to innervate their most distal target (muscle 12) in 59% of hemisegments in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[2] as the paternally derived copy of Dab). These embryos show a "stop short" phenotype in the dorsal branch of the SNa motor nerve, with the axons stopping short and failing to reach their muscle target in 33% of hemisegments. Embryos lacking both maternal and zygotic Dab function (derived from a Dab[1]/Dab[2] stock) show defects during cellularisation; anucleated pseudocells, incomplete pseudocleavage furrows and multinucleated cells are seen during cellularisation, with 92% of embryos having defective cells. The formation of the peri-nuclear tubulin baskets appears to be normal. Abnormal apical actin accumulation is seen throughout cellularisation in these embryos and variable lateral actin accumulation is also seen. Embryos lacking both maternal and zygotic Dab function (derived from a Dab[1]/Dab[2] stock) show defects in dorsal closure with occasional breaks of the leading edge, failure of cell elongation and disturbances in the "zippering" of the dorsal epithelia. (Song et al., 2010) Adult escapers are occasionally seen. (Song, 2010.11.22)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, enhanceable by Df(3L)st100.62/+ (Song et al., 2010) Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, enhanceable by In(3L)std11/+ (Song et al., 2010) Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, enhanceable by trio1/trio[+] (Song et al., 2010) Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, enhanceable by trio8/trio[+] (Song et al., 2010)
Suppressed by
Statement Reference Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, suppressible | partially by ena[+]/enaGC1 (Song et al., 2010) Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, suppressible | partially by ena[+]/enaGC5 (Song et al., 2010) Dab2/Dab1 has neuroanatomy defective | maternal effect | embryonic stage phenotype, suppressible | partially by Scer\GAL4elav.PU/AblScer\UAS.cFa (Song et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, enhanceable by Df(3L)st100.62/+ (Song et al., 2010) Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, enhanceable by In(3L)std11/+ (Song et al., 2010) Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, enhanceable by trio1/trio[+] (Song et al., 2010) Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, enhanceable by trio8/trio[+] (Song et al., 2010) Dab2/Dab1 has segmental nerve branch SNa of A1-7 | maternal effect phenotype, enhanceable by Df(3L)st100.62/+ (Song et al., 2010) Dab2/Dab1 has segmental nerve branch SNa of A1-7 | maternal effect phenotype, enhanceable by In(3L)std11/+ (Song et al., 2010) Dab2/Dab1 has segmental nerve branch SNa of A1-7 | maternal effect phenotype, enhanceable by trio1/trio[+] (Song et al., 2010)
Suppressed by
Statement Reference Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, suppressible | partially by ena[+]/enaGC1 (Song et al., 2010) Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, suppressible | partially by ena[+]/enaGC5 (Song et al., 2010) Dab2/Dab1 has intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype, suppressible | partially by Scer\GAL4elav.PU/AblScer\UAS.cFa (Song et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference The penetrance of the ISNb stall and SNa dorsal branch stop short phenotypes seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is increased by In(3L)std11/+ to 77% and 69% respectively. The penetrance of the ISNb stall and SNa dorsal branch stop short phenotypes seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is increased by Df(3L)st100.62/+ to 65% and 57% respectively. The penetrance of the ISNb stall and SNa dorsal branch stop short phenotypes seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is increased by trio[1]/+ to 78% and 80% respectively. The penetrance of the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is increased by trio[8]/+ to 80%. The penetrance of the ISNb stall and SNa dorsal branch stop short phenotypes seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[2] as the paternally derived copy of Dab) is increased by In(3L)std11/+ to 78% and 62% respectively. The penetrance of the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is decreased by ena[GC5]/+ to 26%. The penetrance of the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is decreased by ena[GC1]/+ to 36%. The penetrance of the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab) is decreased by expression of Abl[Scer\UAS.cFa] under the control of Scer\GAL4[elav.PU] to 29%. (Song et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	Dab2/Dab1 is partially rescued by DabScer\UAS.cWa/Scer\GAL4elav.PU (Song et al., 2010) Dab2/Dab1 is partially rescued by DabScer\UAS.cWa/Scer\GAL4sca-537.4 (Song et al., 2010)
Comments	Expression of Dab[Scer\UAS.cWa] under the control of Scer\GAL4[elav.PU] partially rescues the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[1] as the paternally derived copy of Dab). Expression of Dab[Scer\UAS.cWa] under the control of Scer\GAL4[sca-537.4] partially rescues the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab[1]/Dab[2] females and having Dab[2] as the paternally derived copy of Dab). (Song et al., 2010)
Stocks ( 1 )
Bloomington	32654 w1118; Dab2/TM3, Sb1
Notes on Origin
Discoverer
External Crossreferences & Linkouts
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Dab2 (Song et al., 2010, Song, 2010.11.22)
Name Synonym
Secondary FlyBase IDs
References ( 2 )
Research paper	Song et al., 2010, Development 137(21): 3719--3727 Disabled is a bona fide component of the Abl signaling network. [FBrf0212092]
Personal communication to FlyBase	Song, 2010.11.22, Dab[1] and Dab[2]. Dab[1] and Dab[2]. [FBrf0212475]