FB2025_02 , released April 17, 2025
Allele: Dmel\Vrp1UAS.cMa
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General Information
Symbol
Dmel\Vrp1UAS.cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0247588
Feature type
allele
Associated gene
Dmel\Vrp1
Associated Insertion(s)
Carried in Construct
P{UAS-D-WIP}
Also Known As
UAS-D-WIP
Key Links
Transgenic product class
wild_type
(Massarwa et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Massarwa et al., 2007)
Mutagen
in vitro construct
(Massarwa et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-D-WIP}
Cytology
Description

UAS regulatory sequences drive expression of Vrp1 coding sequences.

(Massarwa et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Vrp1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Vrp1Scer\UAS.cMa under the control of Scer\GAL4Mef2.PR in a Vrp1S1946/Vrp1D30 mutant background produces male sterile flies. The testis contain mature cysts that do not undergo appreciable coiling, cysts do not occupy the base of the testis tube and the seminal vesicle is completely empty of released sperm. The microfilaments and nuclei of late-stage cysts show significant structural alterations. There is a consistent failure to achieve the intertwined and tightly packed organisation of head cyst cell F-actin arrays and associated spermatid nuclei. The microfilament arrays appear sparse and misshapen, and the normally tight and uniformly oriented bundles of nuclei are loosely packed and partially split.

      (Rotkopf et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Vrp1UAS.cMa/Scer\GAL4twi.PB rescues Vrp1D30

      (Massarwa et al., 2007)
      Comments

      Expression of Vrp1Scer\UAS.cMa exclusively in myotubes under the control of Scer\GAL4kirre.PR in a Vrp1D30 mutant background results in significant, although incomplete, rescue.

      (Massarwa et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Vrp1Scer\UAS.cMa
      Vrp1UAS.cMa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)