A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\GaleΔy

General Information
SymbolDmel\GaleΔySpeciesD. melanogaster
NameFlyBase IDFBal0247660
Feature typealleleAssociated geneDmel\Gale
Also Known AsdGALEΔy
Allele classhypomorphic allele - molecular evidence
MutagenDelta2-3
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
hypomorphic allele - molecular evidence
(Sanders et al., 2010)
Mutagen
Delta2-3
(Sanders et al., 2010)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
P{EPgy2}GaleEY22205
(Sanders et al., 2010)
Nature of the lesion
Statement
Reference
Imprecise excision allele generated by mobilizing P{EPgy2}Gale[EY22205], creating a 1339 bp deletion that includes the first coding exon.
(Sanders et al., 2010)
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal (with Df(3L)ED4196)
(Sanders et al., 2010)
lethal (with Df(3L)emc-E12)
(Sanders et al., 2010)
lethal (with Galef00624)
(Daenzer et al., 2012)
lethal (with Galeh)
(Sanders et al., 2010)
lethal | germline clone | late embryonic stage (with Galef00624)
(Sanders et al., 2010)
lethal | recessive
(Sanders et al., 2010)
lethal | second instar larval stage (with Galef00624)
(Sanders et al., 2010)
small body | larval stage (with Galef00624)
(Sanders et al., 2010)
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
Some zygotic Gale[Δy]/Gale[f00624] animals die as embryos, whereas others survive to first-second larval instar stages. Surviving L1 and L2 larvae are abnormally small and lethargic. Gale[Δy]/Gale[f00624] zygotic animals derived from Gale[f00624] germline clones die uniformly in late embryogenesis displaying no morphological defects.
(Sanders et al., 2010)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideSuppressed by
Statement
Reference
Galef00624/GaleΔy has lethal phenotype, suppressible | partially by Hsap\GALEScer\UAS.cSa/Scer\GAL4drm.7.1
(Sanders et al., 2010)
Galef00624/GaleΔy has lethal phenotype, suppressible by Ecol\galEScer\UAS.cDa/Scer\GAL4Act5C.PI/Zzzz\wbgUScer\UAS.cDa
(Daenzer et al., 2012)
Galef00624/GaleΔy has lethal phenotype, suppressible by Hsap\GALEScer\UAS.cSa/Scer\GAL4Act5C.PI
(Sanders et al., 2010)
Galef00624/GaleΔy has lethal phenotype, suppressible by Hsap\GALEScer\UAS.cSa/Scer\GAL4arm.PS
(Sanders et al., 2010)
hideNOT suppressed by
Statement
Reference
Galef00624/GaleΔy has lethal phenotype, non-suppressible by Ecol\galEScer\UAS.cDa/Scer\GAL4Act5C.PI
(Daenzer et al., 2012)
Galef00624/GaleΔy has lethal phenotype, non-suppressible by Hsap\GALEScer\UAS.cSa/Scer\GAL4c754
(Sanders et al., 2010)
Galef00624/GaleΔy has lethal phenotype, non-suppressible by Scer\GAL4Act5C.PI/Zzzz\wbgUScer\UAS.cDa
(Daenzer et al., 2012)
Galef00624/GaleΔy has lethal phenotype, non-suppressible by Scer\GAL4elav-C155/Hsap\GALEScer\UAS.cSa
(Sanders et al., 2010)
hide Phenotype Manifest In
hide Additional Comments
hide Genetic Interactions
Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
Expression of Hsap\GALE[Scer\UAS.cSa] using either Scer\GAL4[arm.PS] or Scer\GAL4[Act5C.PI] rescues the lethality of Gale[Δy]/Gale[f00624] animals. Rescued animals are viable, fertile, and appear morphologically normal. Expression of Hsap\GALE[Scer\UAS.cSa] using Scer\GAL4[drm.7.1] partially rescues the lethality of Gale[Δy]/Gale[f00624] animals, whereas use of Scer\GAL4[elav-C155] or Scer\GAL4[c754] is completely insufficient to rescue or delay lethality of this genotype.
(Sanders et al., 2010)
hide Complementation & Rescue Data
Comments
hide Stocks ( 1 )
Bloomington
37738
w*; wgSp-1/CyO; GaleΔy/TM6B, Tb1
hide Notes on Origin
Discoverer
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
dGALEΔy
(Sanders et al., 2010, Daenzer et al., 2012)
GaleΔy
 
Name Synonym
Secondary FlyBase IDs
hide References ( 2 )
Research paper
Daenzer et al., 2012, PLoS Genet. 8(5): e1002721
UDP-Galactose 4'-Epimerase Activities toward UDP-Gal and UDP-GalNAc Play Different Roles in the Development of Drosophila melanogaster. [FBrf0218493]
Sanders et al., 2010, Dis. Model Mech. 3(9-10): 628--638
UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. [FBrf0211672]