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General Information
Symbol
Dmel\fweUASp.Lose-A.C.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0247689
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of the "Lose-A" isoform of fwe tagged with Tag:HA at its C-terminus.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The amount of cell delamination seen in the 'loser' cells when cell competition is induced in the pupal notum through generation of clones expressing fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1 under the control of Scer\GAL4Scer\FRT.Act5C in wild type tissue correlates with the amount of surface the fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1-expressing loser cell shares with the wild type winners. The amount of shared surface does not affect delamination rates in wild type controls. The compactness of fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1 clones is unchanged compared with wild type clones in wild type tissue.

There is no increase in cell elimination at the anterior-posterior border compared with controls when fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1 is expressed under the control of Scer\GAL4dpp.PU in the anterior compartment of the wing disc, due to high tension at the anterior-posterior boundary.

Expression of fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in clones of cells in the wing imaginal disc induces apoptosis and reduces clone survival.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

A zip2/zipEbr mutant background (which reducing tension in cells) induces cell death at the anterior boundary when fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1 is expressed under the control of Scer\GAL4dpp.PU in the anterior compartment of the wing disc.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
fweScer\UAS.P\T.Lose-A.C.T:Ivir\HA1
fweScer\UAS.T:Ivir\HA.cRb
fweScer\UAS.cRb.T:Ivir\HA1
fweUASp.Lose-A.C.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (3)