Allele Mmus\Ahr^Scer\UAS.cCa

General Information
Symbol	Mmus\Ahr^Scer\UAS.cCa	Species	M. musculus
Name	Saccharomyces cerevisiae UAS construct a of Cespedes	FlyBase ID	FBal0247967
Feature type	allele	Associated gene	Mmus\Ahr

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Céspedes et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of Mmus\Ahr. (Céspedes et al., 2010)
Carried in construct	P{UAS-Ahr.C} (Céspedes et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| chemical conditional, with Scer\GAL4^GMR.PU (Céspedes et al., 2010) visible \| chemical conditional, with Scer\GAL4^rn-GAL4 (Céspedes et al., 2010)
Phenotype Manifest In
	eye \| chemical conditional, with Scer\GAL4^GMR.PU (Céspedes et al., 2010) interommatidial bristle \| chemical conditional, with Scer\GAL4^GMR.PU (Céspedes et al., 2010) leg \| chemical conditional, with Scer\GAL4^rn-GAL4 (Céspedes et al., 2010)
Detailed Description
	Statement Reference Expression of Mmus\Ahr[Scer\UAS.cCa] under the control of Scer\GAL4[rn-GAL4] (in the absence of dioxin) has no effect on leg morphogenesis. However, when these flies are exposed to dioxin, abnormal legs are produced. Expression of Mmus\Ahr[Scer\UAS.cCa] under the control of Scer\GAL4[GMR.PU] (in the absence of dioxin) has little effect on eye morphogenesis. However, when these flies are exposed to dioxin, eye defects are seen, including fused ommatidia and enlarged bristles. (Céspedes et al., 2010)
External Data
Linkouts
Interactions
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Phenotypic Class
Other
Statement Reference Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^GMR.PU, tgo^Scer\UAS.cWa has visible phenotype (Céspedes et al., 2010) Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^rn-GAL4, tgo^Scer\UAS.cWa has visible phenotype (Céspedes et al., 2010) Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^rn-GAL4, Vvvv\Arnt^Scer\UAS.cCa has visible phenotype (Céspedes et al., 2010)
Phenotype Manifest In
Other
Statement Reference Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^GMR.PU, tgo^Scer\UAS.cWa has eye phenotype (Céspedes et al., 2010) Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^GMR.PU, tgo^Scer\UAS.cWa has interommatidial bristle phenotype (Céspedes et al., 2010) Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^rn-GAL4, tgo^Scer\UAS.cWa has leg phenotype (Céspedes et al., 2010) Mmus\Ahr^Scer\UAS.cCa, Scer\GAL4^rn-GAL4, Vvvv\Arnt^Scer\UAS.cCa has leg phenotype (Céspedes et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of Mmus\Ahr[Scer\UAS.cCa] under the control of Scer\GAL4[rn-GAL4] can partially rescue the loss of tarsal segments seen in the legs of ss[sta]/ss[abr] flies. A greater degree of rescue is seen if the flies are exposed to dioxin. Flies co-expressing tgo[Scer\UAS.cWa] and Mmus\Ahr[Scer\UAS.cCa] under the control of Scer\GAL4[rn-GAL4] (in the absence of dioxin) show defects in the leg. Flies co-expressing tgo[Scer\UAS.cWa] and Mmus\Ahr[Scer\UAS.cCa] under the control of Scer\GAL4[GMR.PU] (in the absence of dioxin) show eye defects, with fused ommatidia and enlarged bristles. Flies co-expressing Vvvv\Arnt[Scer\UAS.cCa] and Mmus\Ahr[Scer\UAS.cCa] under the control of Scer\GAL4[rn-GAL4] (in the absence of dioxin) show defects in the leg. (Céspedes et al., 2010)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Mmus\Ahr^Scer\UAS.cCa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Cespedes
Secondary FlyBase IDs

References ( 1 )
Research paper	Céspedes et al., 2010, PLoS ONE 5(11): e15382 Dioxin Toxicity In Vivo Results from an Increase in the Dioxin-Independent Transcriptional Activity of the Aryl Hydrocarbon Receptor. [FBrf0212269]

Allele Mmus\AhrScer\UAS.cCa

Allele Mmus\Ahr^Scer\UAS.cCa