Expression of Nf1Scer\UAS.cBa in α/β neurons under the control of Scer\GAL4c739 in wild-type flies does not enhance normal memory performance.
Flies expressing Nf1Scer\UAS.cBa under the control of Scer\GAL4c305a in a Nf1P1 background exhibits severely reduced fecundity.
Nf1UAS.cBa/Scer\GAL4c305a fails to rescue Nf1c00617
Nf1UAS.cBa/Scer\GAL4NP1131 fails to rescue Nf1c00617
Nf1UAS.cBa/Scer\GAL417d fails to rescue Nf1c00617
Nf1UAS.cBa/Scer\GAL417d fails to rescue Nf1P1
Scer\GAL80Mef2.mb247, Scer\GAL4c747, Scer\GAL80Mef2.mb247, Nf1UAS.cBa fails to rescue Nf1c00617
Expression of Nf1Scer\UAS.cBa in mushroom body neurons during development and adulthood under the control of inducible Scer\GAL4Mef2.247.Switch (in a RU486 environment) completely rescues the 3 hour memory phenotype seen in Nf1c00617 mutants. Expression only during adulthood is sufficient for complete rescue.
Expression of Nf1Scer\UAS.cBa in α'/β' neurons under the control of Scer\GAL4c305a is not sufficient to rescue the 3 hour memory phenotype of Nf1c00617 homozygous mutants.
Expression of Nf1Scer\UAS.cBa in γ neurons under the control of Scer\GAL4NP1131 is not sufficient to rescue the 3 hour memory phenotype of Nf1c00617 homozygous mutants.
Expression of Nf1Scer\UAS.cBa throughout the central brain under the control of Scer\GAL4Mz1081 is sufficient to rescue the 3 hour memory phenotype of both Nf1c00617 and Nf1P1 mutants.
Expression of Nf1Scer\UAS.cBa throughout the central brain under the control of Scer\GAL4NP0009 is sufficient to rescue the 3 hour memory phenotype of both Nf1c00617 and Nf1P1 mutants.
Expression of Nf1Scer\UAS.cBa in the α/β mushroom body neurons under the control of Scer\GAL4c739 is sufficient to rescue the 3 hour memory phenotype of both Nf1c00617 and Nf1P1 mutants. Expression of Nf1Scer\UAS.cBa in α/β neurons under the control of Scer\GAL4c739 fully rescues the Nf1P1 3 minute memory phenotype after training. Expression of Nf1Scer\UAS.cBa under the control of Scer\GAL4c739 in α/β-neurons fully rescues long-term memory in Nf1P1 mutants.
Expression of Nf1Scer\UAS.cBa in the central core of α/β mushroom body neurons under the control of Scer\GAL417d is not sufficient to rescue the 3 hour memory phenotype of either Nf1c00617 and Nf1P1 mutants.
The Nf1c00617 3 hour memory phenotype is fully rescued when Scer\GAL4c747 is used to express Nf1Scer\UAS.cBa. However, flies also carrying Scer\GAL80Mef2.PT exhibit a performance score that is indistinguishable from Nf1c00617 homozygous mutants.