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General Information
Symbol
Dmel\Nf1UAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0247993
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Nf1 coding sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Nf1Scer\UAS.cBa in α/β neurons under the control of Scer\GAL4c739 in wild-type flies does not enhance normal memory performance.

Flies expressing Nf1Scer\UAS.cBa under the control of Scer\GAL4c305a in a Nf1P1 background exhibits severely reduced fecundity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Nf1Scer\UAS.cBa in mushroom body neurons during development and adulthood under the control of inducible Scer\GAL4Mef2.247.Switch (in a RU486 environment) completely rescues the 3 hour memory phenotype seen in Nf1c00617 mutants. Expression only during adulthood is sufficient for complete rescue.

Expression of Nf1Scer\UAS.cBa in α'/β' neurons under the control of Scer\GAL4c305a is not sufficient to rescue the 3 hour memory phenotype of Nf1c00617 homozygous mutants.

Expression of Nf1Scer\UAS.cBa in γ neurons under the control of Scer\GAL4NP1131 is not sufficient to rescue the 3 hour memory phenotype of Nf1c00617 homozygous mutants.

Expression of Nf1Scer\UAS.cBa throughout the central brain under the control of Scer\GAL4Mz1081 is sufficient to rescue the 3 hour memory phenotype of both Nf1c00617 and Nf1P1 mutants.

Expression of Nf1Scer\UAS.cBa throughout the central brain under the control of Scer\GAL4NP0009 is sufficient to rescue the 3 hour memory phenotype of both Nf1c00617 and Nf1P1 mutants.

Expression of Nf1Scer\UAS.cBa in the α/β mushroom body neurons under the control of Scer\GAL4c739 is sufficient to rescue the 3 hour memory phenotype of both Nf1c00617 and Nf1P1 mutants. Expression of Nf1Scer\UAS.cBa in α/β neurons under the control of Scer\GAL4c739 fully rescues the Nf1P1 3 minute memory phenotype after training. Expression of Nf1Scer\UAS.cBa under the control of Scer\GAL4c739 in α/β-neurons fully rescues long-term memory in Nf1P1 mutants.

Expression of Nf1Scer\UAS.cBa in the central core of α/β mushroom body neurons under the control of Scer\GAL417d is not sufficient to rescue the 3 hour memory phenotype of either Nf1c00617 and Nf1P1 mutants.

The Nf1c00617 3 hour memory phenotype is fully rescued when Scer\GAL4c747 is used to express Nf1Scer\UAS.cBa. However, flies also carrying Scer\GAL80Mef2.PT exhibit a performance score that is indistinguishable from Nf1c00617 homozygous mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Nf1Scer\UAS.cBa
Nf1UAS.cBa
Name Synonyms
Secondary FlyBase IDs
    References (1)