FlyBase Allele Report: Dmel\Fer1HCH[UAS.cRa]

General Information

Symbol

Dmel\Fer1HCH^UAS.cRa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Rival

FlyBase ID

FBal0248072

Feature type

allele

Associated gene

Dmel\Fer1HCH

Associated Insertion(s)

Carried in Construct

P{UAS-Fer1HCH.R}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Rival et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-Fer1HCH.R}

Cytology

Description

UASt regulatory sequences drive expression of an isoform that lacks the iron response element resulting in the expression of a constitutively active form of Fer1HCH.

(Rival et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Fer1HCH

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Rival et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fer1HCH^UAS.cRa, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Fer1HCH^UAS.cRa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Fer1HCH^UAS.cRa, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Overexpression of Fer1HCH^Scer\UAS.cRa suppresses the decreased survival phenotype of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of Fer1HCH^Scer\UAS.cRa suppresses the decline in locomotor function of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of Fer1HCH^Scer\UAS.cRa suppresses the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

(Rival et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Fer1HCH^Scer\UAS.cRa

Fer1HCH^UAS.cRa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Rival

Secondary FlyBase IDs

References (2)

Report Sections

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