FB2025_01 , released February 20, 2025
Allele: Hsap\APPF4DE22G.UAS.Tag:SS(nec)
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General Information
Symbol
Hsap\APPF4DE22G.UAS.Tag:SS(nec)
Species
H. sapiens
Name
FlyBase ID
FBal0248086
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-Aβ.F4DE22G}
Key Links
Transgenic product class
missense_variant
(Luheshi et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Luheshi et al., 2007)
Mutagen
in vitro construct
(Luheshi et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Aβ.F4DE22G}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Hsap\APP that is fused to a signal peptide (Tag:SS(nec)) and carries F4D/E22G amino acid substitutions.

(Luheshi et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\APP
Tagged with
Tag:SS(nec)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease
      CEA
      (McKoy et al., 2012, Luheshi et al., 2007)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Female flies expressing Hsap\APPF4DE22G.Scer\UAS.T:SS-nec in the developing nervous system, under the control of Scer\GAL4elav-C155 are short lived as compared to controls. These flies exhibit more abundant protofibrils (HMW oligomers), which have been shown to be more toxic than fibrils, than in controls. Exposing these flies to 2, 20, and 200υM of the compound D737 from the embryonic stage onwards extends longevity. These flies also show a dramatic improvement in climbing ability.

      (McKoy et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\APPF4DE22G.Scer\UAS.T:SS-nec
      Hsap\APPF4DE22G.Scer\UAS.T:nec
      Hsap\APPF4DE22G.UAS.Tag:SS(nec)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)