FlyBase Allele Report: Dmel\Sin3A[HMS00359]

General Information

Symbol

Dmel\Sin3A^HMS00359

Species

D. melanogaster

Name

FlyBase ID

FBal0248124

Feature type

allele

Associated gene

Dmel\Sin3A

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00359}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00359}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00359

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Torres-Campana et al., 2022)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

posterior crossvein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing margin, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing vein L5, with Scer\GAL4^en.PU

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of Sin3A^HMS00359 results in: small and rough eye phenotype (with the Scer\GAL4^GMR.PF driver), incomplete L5 vein, occasional ectopic venation at posterior crossvein and occasional notched wing (with Scer\GAL4^nub.PK). Scer\GAL4^Act5C.PI-driven expression is lethal; no overt adult phenotype is observed with either Scer\GAL4^GMR.PF or Scer\GAL4^nub.PK.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^en.PU, Sin3A^HMS00359 has visible | adult stage phenotype, enhanceable by Scer\GAL4^en.PU/htt^GD14943

(Dietz et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, Sin3A^HMS00359 has visible | adult stage phenotype, suppressible by htt^GD14943/Scer\GAL4^ey.PH

(Dietz et al., 2015)

Scer\GAL4^ey.PH, Sin3A^HMS00359 has visible | adult stage phenotype, suppressible by htt^int

(Dietz et al., 2015)

Scer\GAL4^en.PU, Sin3A^HMS00359 has visible | adult stage phenotype, suppressible by htt^int

(Dietz et al., 2015)

Scer\GAL4^en.PU, Sin3A^HMS00359 has visible | adult stage phenotype, suppressible by Scer\GAL4^en.PU/htt^GD14943

(Dietz et al., 2015)

Other

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Sin3A^HMS00359, dhd^+t4.3, dhd^J5 has female semi-sterile phenotype

(Torres-Campana et al., 2022)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^en.PU, Sin3A^HMS00359 has posterior crossvein phenotype, enhanceable by Scer\GAL4^en.PU/htt^GD14943

(Dietz et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, Sin3A^HMS00359 has eye phenotype, suppressible by htt^GD14943/Scer\GAL4^ey.PH

(Dietz et al., 2015)

Scer\GAL4^ey.PH, Sin3A^HMS00359 has eye phenotype, suppressible by htt^int/htt[+]

(Dietz et al., 2015)

Scer\GAL4^en.PU, Sin3A^HMS00359 has wing phenotype, suppressible by htt^int

(Dietz et al., 2015)

Scer\GAL4^en.PU, Sin3A^HMS00359 has wing vein L5 phenotype, suppressible by Scer\GAL4^en.PU/htt^GD14943

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The adult eye phenotype induced by expression of Sin3A^HMS00359 under the control of Scer\GAL4^ey.PH is suppressed by co-expression of htt^GD14943 or by combination with a single copy of htt^int, the wing phenotype observed with the Scer\GAL4^en.PU driver is also suppressed by combination with htt^int, while the co-expression of htt^GD14943 suppresses the L5 wing vein defect but enhances the ectopic posterior crossvein phenotype.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

NIG-Fly

HMS00359

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00359}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Sin3A^HMS00359

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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