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General Information
Symbol
Dmel\Snr1HMS00363
Species
D. melanogaster
Name
FlyBase ID
FBal0248128
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Snr1HMS00363 under the control of Scer\GAL4insc-Mz1407 leads to a severe increase in the number of type II neuroblasts per third instar larval brain lobe coupled to brain enlargement, as compared to controls.

Somatic (flip-out) clones of cells expressing Snr1HMS00363 under the control of Scer\GAL4Act.PU are highly apoptotic in the wing pouch but cause mainly cell non-autonomous increase in proliferation and tissue overgrowth in the notum region of third instar larval wing disc.

Expression of Snr1HMS00363 under the control of Scer\GAL4SPARC-MI00329-GAL4 does not result in melanisation of the fat body.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
NOT suppressed by
Other
Phenotype Manifest In
Enhanced by
Suppressed by
NOT suppressed by
Other
Additional Comments
Genetic Interactions
Statement
Reference

The increased number of type II neuroblasts and brain enlargement in third instar larval brain lobes resulting from the expression of Snr1HMS00363 under the control of Scer\GAL4insc-Mz1407 is almost fully suppressed by the co-expression of Su(Tpl)HMS00277.

Xenogenetic Interactions
Statement
Reference

Co-expression of Snr1HMS00363 and BacA\p35Scer\UAS.cHa driven by Scer\GAL4Act.PU in somatic (flip-out) clones in either wing or eye discs of third instar larvae leads to aggressive tissue overgrowth. This overgrowth is (in the wing discs) significantly suppressed by co-expression of any of the following: Stat92EdsRNA.Scer\UAS, NJF02959, pucScer\UAS.cMa or bskDN.Scer\UAS.cUa but not by co-expression of either Ilp8GD1670 or Mmp1JF01336.

Massive tissue overgrowth is also observed in wing discs expressing the Snr1HMS00363 and BacA\p35Scer\UAS.cHa under the control of either Scer\GAL4en.PU or Scer\GAL4ptc.PU, this also leads to developmental delay as some of the animals stay in larval stage for up to 10 days.

Complementation and Rescue Data
Partially rescued by
Comments

Co-expression of Snr1HMS00363 and BacA\p35Scer\UAS.cHa driven by Scer\GAL4Act.PU in somatic (flip-out) clones in either wing discs of third instar larvae leads to aggressive tissue overgrowth, which can be rescued by expression of Snr1Scer\UAS.P\T.T:Ivir\HA1, partially rescued by expression Snr1ΔC.Scer\UAS.P\T.T:Ivir\HA1 but cannot be rescued by expression of Snr1ΔNES.Scer\UAS.P\T.T:Ivir\HA1.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Snr1HMS00363
Name Synonyms
Secondary FlyBase IDs
    References (6)