FB2025_01 , released February 20, 2025
Allele: Dmel\Pp1-87BHMS00409
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General Information
Symbol
Dmel\Pp1-87BHMS00409
Species
D. melanogaster
Name
FlyBase ID
FBal0248170
Feature type
allele
Associated gene
Dmel\Pp1-87B
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00409}
Also Known As
HMS00409, UAS-Pp1-87B RNAi, Pp1-87B RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS00409}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00409
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  type 2 diabetes mellitus
      CEA
      (Tsao et al., 2023)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ97.ex1.UAS.mCherry
      (Branco-Santos et al., 2017)
      exacerbates  cancer
      modeled by RbfHMS03004
      (Parkhitko et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Pp1-87BHMS00409 under the control of Scer\GAL4tim.UAS or under the combined control of Scer\GAL4Pdf.PU and Dicer-2 (for more efficient RNAi) show longer circadian periods.

      Adulthood-only expression of Pp1-87BHMS00409 under the combined control of Scer\GAL4tim.PU and Dicer-2 (for more efficient RNAi) and Gal80[ts] (for the temporal control of expression) show longer circadian periods.

      (Xue et al., 2019)

      Females heterozygous for Pp1-87BHMS00409 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to Pp1-87BHMS00409 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PP1-87BRNAi-1
      (Xue et al., 2019)
      Pp1-87BHMS00409
      Name Synonyms
      Secondary FlyBase IDs
        References (14)