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General Information
Symbol
Dmel\Sirt1HMS00484
Species
D. melanogaster
Name
FlyBase ID
FBal0248236
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Sirt1HMS00484 under the control of Scer\GAL4elav-C155 results in significantly decreased sedation sensitivity to acute ethanol exposure in naive flies, and a significant decrease in sedation tolerance when repeatedly exposed to ethanol, as compared to controls.

Driving expression of Sirt1HMS00484 in the fat body (using Scer\GAL4r4) but not elsewhere (Scer\GAL4Mef2.PR, Scer\GAL4mex1.2.1, Scer\GAL4Ilp2.215-1, Scer\GAL4Akh.PL) disrupts insulin signaling and leads to hyperglycemia compared to controls (at 2 weeks old).

Expression of Sirt1HMS00484 results in: slightly rough eye phenotype (with Scer\GAL4GMR.PF), occasional ectopic vein material in the anterior wing or at the posterior crossvein (with Scer\GAL4nub.PK) or in the posterior wing compartment (with Scer\GAL4en.PU). Scer\GAL4Act5C.PI-driven expression is viable; no overt adult phenotype is observed with the Scer\GAL4ey.PH driver.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Sir2HMS00484
Sirt1HMS00484
Name Synonyms
Secondary FlyBase IDs
    References (6)