FB2021_01, released Feb 18, 2021

Allele: Dmel\Sulf1Golgi.UAS.Tag:Golgi(hGALNT3)

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General Information
Symbol
Dmel\Sulf1Golgi.UAS.Tag:Golgi(hGALNT3)
Species
D. melanogaster
Name
FlyBase ID
FBal0248451
Feature type
allele
Associated gene
Dmel\Sulf1
Associated Insertion(s)
Carried in Construct
P{UAS-Sulf1-Golgi}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Kleinschmit et al., 2010)
in vitro construct - coding region fusion
(Kleinschmit et al., 2010)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-Sulf1-Golgi}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of a Golgi-targeting sequence (Tag:Golgi(hGALNT3)) cloned in-frame with amino acids 27-1115 of Sulf1.

      (Kleinschmit et al., 2010)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Sulf1
      Tagged with
      Tag:Golgi(hGALNT3)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sulf1Golgi.Scer\UAS.T:Hsap\GALNT3 in epidermic cells under the control of Scer\GAL4hh-Gal4 results in severe reduction in the overall dendrite or terminal dendrite density and with the latter driver also the terminal dendrite number within the intersegmental area in the adjacent class IV dendritic arborizing neurons in third instar larvae. This reduction of the dendritic tree, albeit somewhat weaker, is also observed upon only short-term (24 hr) Sulf1Golgi.Scer\UAS.T:Hsap\GALNT3 expression induced in early third instar larvae (using tub_Gal80[ts] to exert temporal control).

      (Poe et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sulf1Golgi.Scer\UAS.T:Hsap\GALNT3
      Sulf1Golgi.UAS.Tag:Golgi(hGALNT3)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)