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General Information
Symbol
Dmel\Bap170hfl1
Species
D. melanogaster
Name
FlyBase ID
FBal0248499
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hfl1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Approximate location of 16bp deletion in Bap170hfl1. Reported as a 16bp deletion in the fourth exon that leaves a mutated Bap170 that is deleted from the last C-terminal 304 amino acids.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

16bp deletion in the fourth exon, resulting in a frameshift which is predicted to remove the most C-terminal 304 amino acids.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous and Bap170hfl1/Df(2R)hfl-37 animals show normal development and growth throughout larval life, but terminate further development within the first 12 hours of the prepupal period, with no evidence of eversion of either the imaginal discs or head capsule. Homozygous leg and wing discs start the elongation phase at 4 hours after puparium formation (as occurs in wild type), but as development proceeds, eversion outside the imago body fails and the imaginal discs remain partially elongated in the mutant prepupae.

Bap170hfl1 adults which have been rescued by expression of Bap170C1.Scer\UAS under the control of Scer\GAL4Dll-md23 have eyes that are slightly larger than normal and have a rough appearance. The ommatidia often have more than the normal number of photoreceptor cells (some have extra outer photoreceptors, some have an extra putative R7 cell) and often have more than the normal four cone cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Bap170hfl1/Bap170[+] is an enhancer of visible phenotype of bs2

Suppressor of
Statement
Reference

Bap170hfl1/Bap170[+] is a suppressor | partially of visible phenotype of EgfrT1/Egfrf24

Bap170hfl1/Bap170[+] is a suppressor of visible phenotype of kniri-1

Bap170hfl1/Bap170[+] is a suppressor of visible phenotype of pnt1277/pntΔ88

Bap170hfl1/Bap170[+] is a suppressor | partially of visible phenotype of Raf12

Bap170hfl1 is a suppressor of visible phenotype of Ras85DN17.sev

Bap170hfl1/Bap170[+] is a suppressor | partially of lethal | heat sensitive phenotype of Raf12

Bap170hfl1/Bap170[+] is a suppressor of visible phenotype of vnC221/vn1

NOT Suppressor of
Statement
Reference

Bap170hfl1/Bap170[+] is a non-suppressor of visible phenotype of rhove-1

Phenotype Manifest In
Enhancer of
Statement
Reference

Bap170hfl1/Bap170[+] is an enhancer of wing vein | ectopic phenotype of bs2

Suppressor of
Statement
Reference

Bap170hfl1 is a suppressor of eye phenotype of Ras85DN17.sev

Bap170hfl1/Bap170[+] is a suppressor | partially of eye photoreceptor cell phenotype of EgfrT1/Egfrf24

Bap170hfl1/Bap170[+] is a suppressor of wing vein L4 phenotype of EgfrT1/Egfrf24

Bap170hfl1/Bap170[+] is a suppressor of wing vein L2 | distal phenotype of kniri-1

Bap170hfl1/Bap170[+] is a suppressor of eye photoreceptor cell phenotype of pnt1277/pntΔ88

Bap170hfl1/Bap170[+] is a suppressor | partially of eye phenotype of Raf12

Bap170hfl1/Bap170[+] is a suppressor | partially of photoreceptor cell phenotype of Raf12

Bap170hfl1/Bap170[+] is a suppressor of wing vein L4 phenotype of vnC221/vn1

Bap170hfl1/Bap170[+] is a suppressor | partially of eye phenotype of EgfrT1/Egfrf24

NOT Suppressor of
Statement
Reference

Bap170hfl1/Bap170[+] is a non-suppressor of wing vein L3 | distal phenotype of rhove-1

Bap170hfl1/Bap170[+] is a non-suppressor of wing vein L4 phenotype of rhove-1

Bap170hfl1/Bap170[+] is a non-suppressor of wing vein L5 phenotype of rhove-1

Additional Comments
Genetic Interactions
Statement
Reference

Bap170hfl1 completely suppresses the rough eye phenotype and loss of photoreceptor R7 cells caused by Ras85DN17.sev.

Bap170hfl1/+ significantly suppresses the rough eye phenotype and loss of photoreceptor cells seen in phl12 flies at 18[o]C.

The lethality caused by phl12 at 25[o]C is partially rescued by Bap170hfl1/+.

Bap170hfl1/+ suppresses the loss of photoreceptor cells seen in pntΔ88/pnt1277 flies.

The loss of wing vein L4 which is seen in vn1/vnC221 animals is rescued by Bap170hfl1/+ in 90% of cases.

Bap170hfl1/+ partially suppresses the rough eye phenotype and loss of photoreceptor cells which is seen in Egfrf24/EgfrT1 flies. The loss of wing vein L4 which is seen in Egfrf24/EgfrT1 flies is rescued by Bap170hfl1/+ in 85% of cases.

Bap170hfl1/+ enhances the ectopic wing vein phenotype of bs2 homozygotes.

The loss of the distal part of wing vein L2 which is seen in kniri-1 homozygotes is almost completely suppressed by Bap170hfl1/+ in 95% of cases.

The loss of wing veins seen in rhove-1 homozygotes is not suppressed by Bap170hfl1/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Bap170+Ra rescues the lethality of Bap170hfl1 homozygotes.

Expression of Bap170C1.Scer\UAS under the control of Scer\GAL4tub.PU rescues the lethality of Bap170hfl1 homozygotes.

Expression of Bap170C2.Scer\UAS under the control of Scer\GAL4tub.PU fails to rescue the lethality of Bap170hfl1 homozygotes.

Expression of Bap170C1.Scer\UAS under the control of Scer\GAL4Dll-md23 rescues the prepupal lethality of Bap170hfl1 homozygotes.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Bap170hfl1 was originally isolated as a lethal mutation on a second chromosome which also carries cl9d1.

Separable from: cl9d1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)