FB2025_01 , released February 20, 2025
Allele: Dmel\Trx2T1
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General Information
Symbol
Dmel\Trx2T1
Species
D. melanogaster
Name
FlyBase ID
FBal0248515
Feature type
allele
Associated gene
Dmel\Trx2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Tsuda et al., 2010)
Mutagen
P-element activity
(Tsuda et al., 2010)
Progenitor genotype
P{GSV1}Trx2GS2114
(Tsuda et al., 2010)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1731bp deletion which includes the second exon containing the translation start site.

(Tsuda et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The longevity of homozygous flies is 36% shorter than that of controls.

      5 day old homozygotes have the same climbing ability as control flies, however, the climbing ability of homozygous flies is significantly lower than that of control flies at 25 and 30 days of age.

      Homozygotes are hypersensitive to paraquat compared to controls, but show normal sensitivity to hydrogen peroxide.

      (Tsuda et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Trx-21
      (Tsuda et al., 2010)
      Trx-2T1
      Trx2T1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)