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General Information
Symbol
Dmel\p38a13
Species
D. melanogaster
Name
FlyBase ID
FBal0248524
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

1.4kb deletion that uncovers the promoter region and 5' portion of the Mpk2 transcript.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

p38a13 mutant flies are more susceptible to Ecc15 infection than wild-type flies.

No lipid accumulation is seen in the intestines of p38a13 mutant flies.

p38b156A homozygous mutants do not exhibit any heart defects.

Mutant flies do not have any visible morphological or developmental abnormalities.

Mutant adults show some decrease in the rate of survival compared to wild-type controls after infection with either Enterobacter cloacae, Listeria monocytogenes or Beauveria bassiana.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

p38a13, p38b156A double mutant flies exhibit abnormal heart function, as characterised by an increased incidence of irregular beats, a broader distribution of HPs, and significantly elevated the arrhythmia index, compared to wild-type flies. The diastolic and systolic diameters are significantly smaller in p38a13, p38b156A double homozygotes than in wild-type, resulting in a narrower heart tube.

A p38b156A, p38a13 double mutant background partially restores a normal heart rhythm and normalizes the diastolic and systolic heart diameters of flies expressing CatScer\UAS.cAa under the control of Scer\GAL4Dot.PK.

Double mutant Mpk213 p38b156A late third instar larvae and adults show melanisation in the hindgut. Vacuoles are detected in the epithelial cells in the melanised regions.

Mpk213 p38b156A double mutant flies show a reduced survival rate compared to control flies after infection with either P. aeruginosa, S. aureus or A. fumigatus. The mutant flies show normal resistance to infection with E. coli.

Mpk213 p38b156A double mutant animals typically die at larval and pupal stages under standard culture conditions, with only a few escapers. Raising the double mutant animals under either near-sterile conditions or with standard food containing antibiotics results in a significant increase in survival rate to the pupal stage.

Mpk213 p38b156A double mutant animals show reduced survival to the pupal stage compared to controls when raised on sterilised food into which P. aeruginosa has been introduced. Introducing E. coli or S. cerevisiae into sterilised food has no effect on survival of Mpk213 p38b156A double mutants.

Double mutant Mpk213 p38b156A larvae show melanisation in the hindgut. There is a significant reduction in this melanisation if the animals are cultured in near-sterile conditions ot on standard food containing antibiotics. Introduction of P. aeruginosa into sterilised food increases the occurrence of melanisation in the Mpk213 p38b156A animals, while introduction of either E. coli or S. cerevisiae has no effect on melanisation in the hindgut.

Mpk213 p38b156A adults show a strongly reduced rate of survival compared to wild-type controls after infection with either Enterobacter cloacae, Listeria monocytogenes or Beauveria bassiana.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)