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General Information
Symbol
Dmel\Keap1EY5
Species
D. melanogaster
Name
FlyBase ID
FBal0248713
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    A Keap1EY5 heterozygous background has no effect on locomotor performance.

    Male Keap1EY5/+ flies show significantly increased survival rates after exposure to oxidative stress. Importantly, male Keap1EY5 heterozygotes also live significantly longer than their otherwise genetically identical siblings. Female Keap1EY5 heterozygotes do not show significant differences in either oxidative stress resistance or longevity.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    NOT Suppressor of
    Statement
    Reference

    Keap1EY5/Keap1[+] is a non-suppressor of visible phenotype of Pink1dsRNA.UAS, Scer\GAL4Mhc.PW

    Phenotype Manifest In
    Suppressor of
    NOT Suppressor of
    Statement
    Reference

    Keap1EY5/Keap1[+] is a non-suppressor of wing phenotype of Pink1dsRNA.UAS, Scer\GAL4Mhc.PW

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The eye phenotype resulting from the overexpression of cln3Scer\UAS.cTa under the control of Scer\GAL4GMR.PF is almost completely suppressed by Keap1EY5/+.

    The abnormal wing posture caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is not suppressed Keap1EY5/+, but the viability of aged flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is increased by Keap1EY5/+.

    Xenogenetic Interactions
    Statement
    Reference

    Flies expressing Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF in a Keap1EY5/+ background display locomotor activity similar to that of wild-type flies, indicating that the Keap1EY5/+ background suppresses the age-dependent decay in negative geotaxis response found in Hsap\SNCAScer\UAS.cTa-expressing flies.

    A Keap1EY5/+ background, the neuron loss experienced in PPL1 clusters upon expression of Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF is restored to wild-type levels.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (7)