FB2025_05 , released December 11, 2025
Allele: Dmel\Keap1EY5
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General Information
Symbol
Dmel\Keap1EY5
Species
D. melanogaster
Name
FlyBase ID
FBal0248713
Feature type
allele
Associated gene
Dmel\Keap1
Associated Insertion(s)
Carried in Construct
Also Known As
dKeap1EY5
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Parkinson's disease
        modeled by Hsap\SNCAUAS.cTa
        (Barone et al., 2011)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Keap1EY5 homozygous adult midgut clones present a significant decrease in cell number at 7 days after clone induction, as compared to control clones.

        (Wang et al., 2014)

        A Keap1EY5 heterozygous background has no effect on locomotor performance.

        (Barone et al., 2011)

        Male Keap1EY5/+ flies show significantly increased survival rates after exposure to oxidative stress. Importantly, male Keap1EY5 heterozygotes also live significantly longer than their otherwise genetically identical siblings. Female Keap1EY5 heterozygotes do not show significant differences in either oxidative stress resistance or longevity.

        (Sykiotis and Bohmann, 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT suppressed by
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        Keap1EY5/Keap1[+] is a non-suppressor of visible phenotype of Pink1RNAi.UAS.cYa, Scer\GAL4Mhc.PW

        (Imai et al., 2010)
        Phenotype Manifest In
        NOT suppressed by
        Statement
        Reference

        Keap1EY5 has midgut | somatic clone | adult stage phenotype, non-suppressible | somatic clone by Scer\GAL4unspecified/Xbp1KK102632

        (Wang et al., 2014)
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        Keap1EY5/Keap1[+] is a non-suppressor of wing phenotype of Pink1RNAi.UAS.cYa, Scer\GAL4Mhc.PW

        (Imai et al., 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The eye phenotype resulting from the overexpression of cln3Scer\UAS.cTa under the control of Scer\GAL4GMR.PF is almost completely suppressed by Keap1EY5/+.

        (Tuxworth et al., 2011)

        The abnormal wing posture caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is not suppressed Keap1EY5/+, but the viability of aged flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is increased by Keap1EY5/+.

        (Imai et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference

        Flies expressing Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF in a Keap1EY5/+ background display locomotor activity similar to that of wild-type flies, indicating that the Keap1EY5/+ background suppresses the age-dependent decay in negative geotaxis response found in Hsap\SNCAScer\UAS.cTa-expressing flies.

        A Keap1EY5/+ background, the neuron loss experienced in PPL1 clusters upon expression of Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF is restored to wild-type levels.

        (Barone et al., 2011)
        Complementation and Rescue Data
        Partially rescued by

        Keap1EY5 is partially rescued by Scer\GAL4Tub.PU/Keap1ΔCTD.UAS.YFP

        (Carlson et al., 2022)

        Keap1EY5 is partially rescued by Scer\GAL4Tub.PU/Keap1UAS.rxYFP

        (Carlson et al., 2022)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        References (10)