FB2025_01 , released February 20, 2025
Allele: Dmel\ovosvb-108
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General Information
Symbol
Dmel\ovosvb-108
Species
D. melanogaster
Name
FlyBase ID
FBal0248716
Feature type
allele
Associated gene
Dmel\ovo
Associated Insertion(s)
PBac{RB3.WH3}ovosvb-108
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Frankel et al., 2010)
Progenitor genotype
Associated Insertion(s)
PBac{RB3.WH3}ovosvb-108
Caused by aberration
Df(1)svb108
Cytology
Description

32kb deletion removing the DG2 and Z enhancers of ovo.

(Frankel et al., 2010)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous first instar larvae raised at 25[o]C have slightly fewer quaternary trichomes than normal and show a reduction in the size of the lateral sensory bristles compared to controls.

      Homozygous first instar larvae raised at extreme temperatures (ether 17[o]C or 32[o]C) have a highly significant decrease in the number of the quarternary trichomes (in the lateral and dorsal regions where the DG2 and Z enhancers drive strong expression) compared to control larvae.

      The primary and tertiary trichomes appear normal on homozygous larvae at all temperatures.

      (Frankel et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      ovosvb-108, wg[+]/wgl-8 has dorsal fine hair phenotype

      (Frankel et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ovosvb-108/Y ; wgl-8/+ larvae raised at 25[o]C have significantly fewer quaternary trichomes compared to controls.

      (Frankel et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      ovosvb-108 is partially rescued by ovoZ.svb

      (Frankel et al., 2010)
      Comments

      The reduction in the number of the quarternary trichomes which is seen in homozygous ovosvb-108 larvae raised at extreme temperatures (ether 17[o]C or 32[o]C) is completely rescued by ovoZ.svb in the lateral patch (where the Z enhancer drives high levels of expression), but is not or only very weakly rescued by ovoZ.svb in the dorsal region of the segment (where the Z enhancer only drives expression weakly).

      (Frankel et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ovosvb-108
      Name Synonyms
      Secondary FlyBase IDs
        References (3)