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General Information
Symbol
Dmel\qless264
Species
D. melanogaster
Name
FlyBase ID
FBal0248814
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
DNA sequencing failed to identify any point mutations in the sequence coding for qless-PA.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Post-embryonic generation of qless109 MARCM clones in the optic lobe, central brain or thoracic neuromeres results in dramatic reduction in neuroblast clonal growth by 96 hours after larval hatching. Whereas a single large mira[+] neuroblast is observed in each wild type clone, this cell type is missing in the majority of thoracic qless109 clones. There is also a large reduction in postmitotic progeny - qless109 clones in the central brain or thoracic neuromeres contain only ~20% or ~14%, respectively, of the wild type number of cells per clone. Dietary supplementation of with Coenzyme Q with side-chain length of 10, 9 or 4 isoprenoid units rescues the presence of a mira[+] neuroblast and the number of cells per clone in qless264 MARCM clones to near wild type levels in both the central brain and thoracic neuromeres. Most neurons in qless264 MARCM clones at 96 hours after larval hatching are undergoing caspase-mediated apoptosis. qless264 cells also experience increased mitochondrial stress, as judged by Hsp60 upregulation.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Expression of BacA\p35Scer\UAS.cHa within qless264 MARCM clones does not prevent mitochondrial stress, but does efficiently rescue the number of cells per qless264 clone.
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)