Post-embryonic generation of qless109
MARCM clones in the optic lobe, central brain or thoracic neuromeres results in dramatic reduction in neuroblast clonal growth by 96 hours after larval hatching. Whereas a single large mira
[+] neuroblast is observed in each wild type clone, this cell type is missing in the majority of thoracic qless109
clones. There is also a large reduction in postmitotic progeny - qless109
clones in the central brain or thoracic neuromeres contain only ~20% or ~14%, respectively, of the wild type number of cells per clone.
Dietary supplementation of with Coenzyme Q with side-chain length of 10, 9 or 4 isoprenoid units rescues the presence of a mira
[+] neuroblast and the number of cells per clone in qless264
MARCM clones to near wild type levels in both the central brain and thoracic neuromeres.
Most neurons in qless264
MARCM clones at 96 hours after larval hatching are undergoing caspase-mediated apoptosis. qless264
cells also experience increased mitochondrial stress, as judged by Hsp60