|Feature type||allele||Associated gene||Hsap\TARDBP|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Expression of Hsap\TARDBP[M.Scer\UAS.T:Zzzz\FLAG] neuronally under the control of Scer\GAL4[elav.Switch.PO] at 25[o]C results in early death. Expression of Hsap\TARDBP[M.Scer\UAS.T:Zzzz\FLAG] neuronally under the control of Scer\GAL4[elav-C155] at 25[o]C results in L1 larval lethality. Expression of Hsap\TARDBP[M.Scer\UAS.T:Zzzz\FLAG] in glia in the developing nervous system under the control of Scer\GAL4[repo] at 25[o]C results in pupal lethality. Expression of Hsap\TARDBP[M.Scer\UAS.T:Zzzz\FLAG] in developing muscle cells under the control of Scer\GAL4[how-24B] at 25[o]C results in larval lethality. Expression of Hsap\TARDBP[M.Scer\UAS.T:Zzzz\FLAG] in the developing eye under the control of Scer\GAL4[GMR.PF] at 25[o]C results in a mild rough eye phenotype with minor disruption in the external lattice with occasionally interommatidial bristles missing. Expression at 29[o]C results in an additional loss of pigment phenotype. These phenotypes worsen over time. Expression of Hsap\TARDBP[M.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[elav.Switch.PO] (in a RU486 background) greatly reduces adult fly longevity. Examination of the brains of 20 day old mutants fails to identify any obvious abnormalities such as vacuolar pathology.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|