FlyBase Allele Report: Dmel\Sod1[UAS.cWa]

General Information

Symbol

Dmel\Sod1^UAS.cWa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Watson

FlyBase ID

FBal0248883

Feature type

allele

Associated gene

Dmel\Sod1

Associated Insertion(s)

Carried in Construct

P{UAS-Sod1}

Also Known As

UAS-SOD1, UAS-Sod

Key Links

Transgenic product class

wild_type

(Watson et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Watson et al., 2008)

Mutagen

in vitro construct

(Watson et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-Sod1}

Cytology

Description

UAS regulatory sequences drive expression of Sod1.

(Watson et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Sod1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

DOES NOT model amyotrophic lateral sclerosis

CEA

(Watson et al., 2008)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cardiomyopathy

modeled by park^HMS01651

(Bhandari et al., 2014)

modeled by park^HMS01800

(Bhandari et al., 2014)

ameliorates Parkinson's disease

modeled by Pgk^KK102941

(Shimizu et al., 2020)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cSb

(Saito et al., 2021)

modeled by Hsap\MAPT^{C291A.UAS.2N4R}, Hsap\MAPT^{C322A.UAS.2N4R}

(Saito et al., 2021)

ameliorates neurodegenerative disease

modeled by ifc^KO

(Tzou et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^Ugt36A1.PK

(Lim et al., 2014)

Phenotype Manifest In

adult heart, with Scer\GAL4^Ugt36A1.PK

(Lim et al., 2014)

Detailed Description

Statement

Reference

Expression of Sod1^Scer\UAS.cWa under the control of either Scer\GAL4^da.PU or Scer\GAL4^ple.PF does not affect the climbing ability of adult flies relative to controls.

(Filograna et al., 2016)

Expression of Sod^Scer\UAS.cWa under the control of Scer\GAL4^tin.CΔ4 has no effect on heart tube contraction.

(Bhandari et al., 2014)

Expression of Sod^Scer\UAS.cWa specifically in nonmyocytic pericardial cells, under the control of Scer\GAL4^Dot.PK increases the incidence of cardiac arrhythmia and causes constriction of the heart tube.

(Lim et al., 2014)

Overexpression of Sod^Scer\UAS.cWa driven by Scer\GAL4^D42 in motor neurons does not cause any motor dysfunction.

(Watson et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, Sod1^UAS.cWa has abnormal oxidative stress response phenotype, enhanceable by Sod2^UAS.cMa/Scer\GAL4^Hand.PA

(Lim et al., 2014)

Enhancer of

Statement

Reference

Scer\GAL4^Hand.PA/Sod1^UAS.cWa is an enhancer of abnormal oxidative stress response phenotype of Scer\GAL4^Ugt36A1.PK, Sod2^UAS.cMa

(Lim et al., 2014)

Suppressor of

Statement

Reference

Sod1^UAS.cWa, Scer\GAL4^ple.PF is a suppressor of abnormal locomotor behavior | larval stage phenotype of Pgk^KK102941, Scer\GAL4^ple.PF

(Shimizu et al., 2020)

Scer\GAL4^mex1.PU/Sod1^UAS.cWa is a suppressor of short lived phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^Myo31DF.PU/Sod1^UAS.cWa is a suppressor of short lived phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^elav.PU/Sod1^UAS.cWa is a suppressor | partially of short lived phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^mex1.PU/Sod1^UAS.cWa is a suppressor of increased cell death | adult stage phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^mex1.PU/Sod1^UAS.cWa is a suppressor of abnormal stress response | adult stage phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^Myo31DF.PU/Sod1^UAS.cWa is a suppressor of increased cell death | adult stage phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^Myo31DF.PU/Sod1^UAS.cWa is a suppressor of abnormal stress response | adult stage phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^Myo31DF.PU/Sod1^UAS.cWa is a suppressor of short lived phenotype of Ecol\lexA^GMR68A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ppk.PU/Sod1^UAS.cWa is a non-suppressor of abnormal neuroanatomy | P-stage phenotype of cnc¹²²³

(Chew et al., 2021)

Scer\GAL4^ppk.PU/Sod1^UAS.cWa is a non-suppressor of abnormal neuroanatomy | P-stage phenotype of Scer\GAL4^ppk.PU, cnc^GD4437

(Chew et al., 2021)

Scer\GAL4^elav.PU/Sod1^UAS.cWa is a non-suppressor of decreased sleep | adult stage | heat sensitive phenotype of Ecol\lexA^GMR50A07, TrpA1^lexAop.cBa

(Vaccaro et al., 2020)

Scer\GAL4^Mef2.PR/Sod1^UAS.cWa is a non-suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Scer\GAL4^Mef2.PR, clu^GD13926

(Wang et al., 2016)

Scer\GAL4^Mef2.PR/Sod1^UAS.cWa is a non-suppressor of partially lethal - majority die phenotype of Scer\GAL4^Mef2.PR, clu^GD13926

(Wang et al., 2016)

Other

Statement

Reference

Pgk^KK102941, Scer\GAL4^ple.PF, Sod1^UAS.cWa has abnormal locomotor behavior | larval stage phenotype

(Shimizu et al., 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, Sod1^UAS.cWa has adult heart phenotype, non-enhanceable by Sod2^UAS.cMa/Scer\GAL4^Hand.PA

(Lim et al., 2014)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Hand.PA/Sod1^UAS.cWa is a non-enhancer of adult heart phenotype of Scer\GAL4^Ugt36A1.PK, Sod2^UAS.cMa

(Lim et al., 2014)

Suppressor of

Statement

Reference

Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4 is a suppressor of adult heart phenotype of Scer\GAL4^tin.CΔ4, park^HMS01651

(Bhandari et al., 2014)

Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4 is a suppressor of cardial cell phenotype of Scer\GAL4^tin.CΔ4, park^HMS01651

(Bhandari et al., 2014)

Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4 is a suppressor of mitochondrion phenotype of Scer\GAL4^tin.CΔ4, park^HMS01651

(Bhandari et al., 2014)

Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4 is a suppressor of adult heart phenotype of Scer\GAL4^tin.CΔ4, park^HMS01800

(Bhandari et al., 2014)

Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4 is a suppressor of cardial cell phenotype of Scer\GAL4^tin.CΔ4, park^HMS01800

(Bhandari et al., 2014)

Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4 is a suppressor of mitochondrion phenotype of Scer\GAL4^tin.CΔ4, park^HMS01800

(Bhandari et al., 2014)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ppk.PU/Sod1^UAS.cWa is a non-suppressor of dendrite | P-stage phenotype of cnc¹²²³

(Chew et al., 2021)

Scer\GAL4^ppk.PU/Sod1^UAS.cWa is a non-suppressor of larval multidendritic class IV neuron | somatic clone | P-stage phenotype of cnc¹²²³

(Chew et al., 2021)

Scer\GAL4^ppk.PU/Sod1^UAS.cWa is a non-suppressor of dendrite | P-stage phenotype of Scer\GAL4^ppk.PU, cnc^GD4437

(Chew et al., 2021)

Scer\GAL4^ppk.PU/Sod1^UAS.cWa is a non-suppressor of larval multidendritic class IV neuron | P-stage phenotype of Scer\GAL4^ppk.PU, cnc^GD4437

(Chew et al., 2021)

Scer\GAL4^Mef2.PR/Sod1^UAS.cWa is a non-suppressor of mitochondrion | adult stage phenotype of Scer\GAL4^Mef2.PR, clu^GD13926

(Wang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expressing Sod1^UAS.cWa suppresses the decreased larval crawling induced by the expression of Pgk^KK102941 under the control of Scer\GAL4^ple.PF, even leading to an increase in crawling.

(Shimizu et al., 2020)

The larval locomotor deficit, very low adult eclosion rate as well as the mitochondrial morphology defects in adult indirect flight muscles (enlarged clustered mitochondria) characteristic for animals expressing clu^GD13926 under the control of Scer\GAL4^Mef2.PR cannot be suppressed by co-expression of Sod1^UAS.cWa.

(Wang et al., 2016)

Expression of Sod^Scer\UAS.cWa suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01651 is expressed under the control of Scer\GAL4^tin.CΔ4.

Expression of Sod^Scer\UAS.cWa suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01800 is expressed under the control of Scer\GAL4^tin.CΔ4.

(Bhandari et al., 2014)

Co-expression of Sod^Scer\UAS.cWa and Sod2^Scer\UAS.cMa in cardiomyocytes and nonmyocytic pericardial cells, under the control of Scer\GAL4^Hand.PA, which results in a significant increase in the level of physiological reactive oxygen species, has no significant effects on any major aspects of heart function, including heart rhythm or heart tube dimensions.

(Lim et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^{Sod1-MI08143-TG4.0}/Sod1^UAS.cWa rescues Sod1^{MI08143-TG4.0}/Df(3L)BSC817

(Lee et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33605

w¹¹¹⁸; P{UAS-Sod1}12.1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Sod1^Scer\UAS.cWa

Sod1^UAS.cWa

Sod^Scer\UAS.cWa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Watson

Secondary FlyBase IDs

References (18)

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