FlyBase Allele Report: Dmel\Wwox[1]

General Information

Symbol

Dmel\Wwox¹

Species

D. melanogaster

Name

FlyBase ID

FBal0248943

Feature type

allele

Associated gene

Dmel\Wwox

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

recombination

(O'Keefe et al., 2005)

I-SceI

(O'Keefe et al., 2005)

FLPase

(O'Keefe et al., 2005)

ends-in gene targeting

(O'Keefe et al., 2005)

Progenitor genotype

Cytology

Description

Introduction of two premature stop codons, a +1 frameshift mutation and a SalI site into the first exon of Wwox.

(O'Keefe et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(O'Keefe et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Wwox¹/Wwox^f04545 animals do not show sensitivity to ionising radiation.

The radiation sensitivity reported for Wwox¹ homozygotes in FBrf0188204 was significantly reduced after four rounds of back-crossing of the mutant flies to wild-type flies. This suggests that the radiation sensitivity attributed to the Wwox¹ mutation in FBrf0188204 was not due to an effect on Wwox but was a consequence of perturbations elsewhere in the genome.

(O'Keefe et al., 2006)

FlyBase curator comment: the radiation sensitivity reported for Wwox¹ homozygotes in FBrf0188204 has subsequently been shown not to be due to the mutation in Wwox, but instead due to perturbations elsewhere in the genome (see FBrf0193053).

(O'Keefe et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Wwox¹/Wwox¹ is an enhancer of short lived phenotype of Sod1ⁿ¹/Sod1ⁿ⁶⁴

(O'Keefe et al., 2011)

Other

Statement

Reference

Idh3b^EY00276, Wwox¹ has lethal phenotype

(O'Keefe et al., 2011)

Sod1ⁿ¹/Sod1ⁿ⁶⁴, Wwox¹ has partially lethal - majority die phenotype

(O'Keefe et al., 2011)

Sod1ⁿ¹/Sod1ⁿ⁶⁴, Wwox¹/Wwox^f04545 has partially lethal - majority die phenotype

(O'Keefe et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

Wwox¹/Wwox[+] is an enhancer of eye phenotype of ND-75^KK108222, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox¹/Wwox[+] is an enhancer of eye phenotype of ND-23^GD11167, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox¹/Wwox[+] is an enhancer of eye phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

CG6439^EY00276 Wwox¹ double homozygous adults are not recovered.

Sodⁿ¹/Sodⁿ⁶⁴ Wwox¹/Wwox¹ double mutant adult escapers show further reduction of the shortened lifespan seen in Sodⁿ¹/Sodⁿ⁶⁴ single mutant adults.

(O'Keefe et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DmWWOX¹

(O'Keefe et al., 2006, O'Keefe et al., 2005)

WWOX¹

(Choo et al., 2015, O'Keefe et al., 2015)

Wwox¹

(O'Keefe et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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