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General Information
Symbol
Dmel\Wwox1
Species
D. melanogaster
Name
FlyBase ID
FBal0248943
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Introduction of two premature stop codons, a +1 frameshift mutation and a SalI site into the first exon of Wwox.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wwox1/Wwoxf04545 animals do not show sensitivity to ionising radiation.

The radiation sensitivity reported for Wwox1 homozygotes in FBrf0188204 was significantly reduced after four rounds of back-crossing of the mutant flies to wild-type flies. This suggests that the radiation sensitivity attributed to the Wwox1 mutation in FBrf0188204 was not due to an effect on Wwox but was a consequence of perturbations elsewhere in the genome.

FlyBase curator comment: the radiation sensitivity reported for Wwox1 homozygotes in FBrf0188204 has subsequently been shown not to be due to the mutation in Wwox, but instead due to perturbations elsewhere in the genome (see FBrf0193053).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

CG6439EY00276 Wwox1 double homozygous adults are not recovered.

Sodn1/Sodn64 Wwox1/Wwox1 double mutant adult escapers show further reduction of the shortened lifespan seen in Sodn1/Sodn64 single mutant adults.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)