Allele Dmel\CtBP^{CAT.T:Zzzz\FLAG}

General Information
Symbol	Dmel\CtBP^{CAT.T:Zzzz\FLAG}	Species	D. melanogaster
Name		FlyBase ID	FBal0248954
Feature type	allele	Associated gene	Dmel\CtBP

Allele class
Mutagen	in vitro construct - amino acid replacement
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Zhang and Arnosti, 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{CtBP.WT.FLAG} (Zhang and Arnosti, 2011)
Nature of the lesion	Statement Reference Carries an H315Q amino acid substitution at a conserved position in the catalytic site. (Zhang and Arnosti, 2011)
Carried in construct	P{CtBP.CAT.FLAG} (Zhang and Arnosti, 2011)
Tagged with	T:Zzzz\FLAG (Zhang and Arnosti, 2011)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	CtBP^{CAT.T:Zzzz\FLAG} partially rescues CtBP⁰³⁴⁶³ (Zhang and Arnosti, 2011)
Comments	A considerable number of adult flies survive despite being homozygous for CtBP[03463] in the presence of CtBP[CAT.T:Zzzz\FLAG]. The hatch rate of maternally rescued CtBP[03463] embryos is somewhat lower compared with that of wild-type embryos. Homozygous CtBP[03463] mutant adults zygotic-rescued by CtBP[CAT.T:Zzzz\FLAG] display a variety of wing defects, ranging from mildly curly wings to blistered wing phenotypes, and, in some cases, severely reduced wings. CtBP[CAT.T:Zzzz\FLAG]-rescued CtBP[03463]-mutant wings frequently display missing and extra macrochaeta bristle phenotypes. (Zhang and Arnosti, 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CtBP^{CAT.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Zhang and Arnosti, 2011, Mol. Cell. Biol. 31(2): 375--384 Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development. [FBrf0212606]

Allele Dmel\CtBPCAT.T:Zzzz\FLAG

Allele Dmel\CtBP^{CAT.T:Zzzz\FLAG}