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General Information
Symbol
Dmel\pydex180
Species
D. melanogaster
Name
FlyBase ID
FBal0248976
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the progenitor insertion, P{GawB}pydNP4400, results in a deletion encompassing a large region of pyd.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Embryos maternally and zygotically mutant for pydex180 exhibit 66% embryonic lethality. Substantial embryonic lethality (43-58%) is found in flies from pydex180 mothers crossed with pydB12 fathers. The ventral epidermis is intact in pydex180 maternal/zygotic mutant embryos and the CNS is not obviously hypertrophied. While approximately 17% of pydex180 maternal/zygotic mutant embryos appear wild-type, most mutant embryos (32%) exhibit defects in head involution that result in defective head skeletons, whereas the most severe (51%) display complete failure of head involution, leading to a hole in the cuticle. In addition, some show minor defects in dorsal closure. The ventral epidermis is intact in pydB12/pydex180 maternal/zygotic mutant embryos and the CNS is not obviously hypertrophied. While approximately 12% of pydB12/pydex180 maternal/zygotic mutant embryos appear wild-type, most mutant embryos (54%) exhibit defects in head involution that result in defective head skeletons, whereas the most severe (34%) display complete failure of head involution, leading to a hole in the cuticle. In addition, some show minor defects in dorsal closure.
Over 90% of pydex180/Df(3R)p-XT103 flies display more than four dorsocentral macrochaetae. Wings from pydex180/Df(3R)p-XT103 flies are broader compared to control wings. A 10% increase in the number of cells found between the L3 and L4 veins is observed.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
pydex180/pyd[+] is an enhancer of cell shape defective phenotype of ena23
Phenotype Manifest In
Enhanced by
Statement
Reference
pydex180 has embryo | dorsal closure stage phenotype, enhanceable by ena23/ena[+]
pydex180 has embryonic leading edge cell phenotype, enhanceable by ena23/ena[+]
pydex180 has ventral head epidermis phenotype, enhanceable by ena23/ena[+]
pydex180 has embryonic head phenotype, enhanceable by ena23/ena[+]
Enhancer of
Statement
Reference
pydex180/pyd[+] is an enhancer of embryo | dorsal closure stage phenotype of ena23
pydex180/pyd[+] is an enhancer of embryonic leading edge cell phenotype of ena23
pydex180/pyd[+] is an enhancer of ventral head epidermis phenotype of ena23
pydex180/pyd[+] is an enhancer of embryonic head phenotype of ena23
Additional Comments
Genetic Interactions
Statement
Reference
Reducing ena levels, through an ena23 heterozygous background, substantially enhances the severity of the pydex180 zygotic/maternal phenotype; more than one-third of the mutants exhibit large holes in the cuticle, suggesting disruption of epithelial integrity. Reducing pyd levels, through a pydex180 heterozygous background, strongly enhances the morphogenesis defects found in zygotic ena23 mutants, substantially increasing the frequency of failure of head involution.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)