FB2025_01 , released February 20, 2025
Allele: Dmel\Liprin-βUAS.Tag:HA
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General Information
Symbol
Dmel\Liprin-βUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0249002
Feature type
allele
Associated gene
Dmel\Liprin-β
Associated Insertion(s)
Carried in Construct
P{UAS-Liprin-β.HA}
Also Known As
UAS-HA-Liprin-β
Key Links
Transgenic product class
cDNA
(Astigarraga et al., 2010)
wild_type
(Astigarraga et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Astigarraga et al., 2010)
wild_type
(Astigarraga et al., 2010)
Mutagen
in vitro construct
(Astigarraga et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Liprin-β.HA}
Cytology
Description

UAS drives expression of a Liprin-β cDNA (RE16685) with an N-terminal Tag:HA tag.

(Astigarraga et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Liprin-β
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Liprin-βScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in RhoGAP100FCD R7 photoreceptor cell clones has no effect on either the failure of the axon terminals to contact the M6 layer of the medulla or the tendency for the R7 axons that do reach the M6 layer to project extensions.

      (Holbrook et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4how-24B/Liprin-βUAS.Tag:HA rescues Liprin-βΔ83

      (Astigarraga et al., 2010)

      Scer\GAL4elav-C155/Liprin-βUAS.Tag:HA rescues Liprin-βΔ83/Liprin-βΔ51

      (Astigarraga et al., 2010)
      Partially rescues

      Scer\GAL4elav-C155/Liprin-βUAS.Tag:HA partially rescues Liprin-βΔ83/Liprin-βΔ51

      (Astigarraga et al., 2010)
      Comments

      Scer\GAL4elav-C155-mediated expression of Liprin-βScer\UAS.T:Ivir\HA1 significantly rescues the aberrant axon termination phenotype seen in Liprin-βΔ83/Liprin-βΔ51 mutants.

      Scer\GAL4elav-C155-mediated expression of Liprin-βScer\UAS.T:Ivir\HA1 restores the number of boutons in Liprin-βΔ83/Liprin-βΔ51 animals to control levels.

      Scer\GAL4how-24B-mediated expression of Liprin-βScer\UAS.T:Ivir\HA1 restores the number of boutons in Liprin-βΔ83 animals to control levels.

      (Astigarraga et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Liprin-βScer\UAS.T:Ivir\HA1
      Liprin-βUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)