Allele Scer\GAL4^da.Switch.PT

General Information
Symbol	Scer\GAL4^da.Switch.PT	Species	S. cerevisiae
Name		FlyBase ID	FBal0249022
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference A 3178bp genomic fragment from immediately 5' of the da ATG start codon is fused upstream of the "GeneSwitch" protein. (Tricoire et al., 2009)
Carried in construct	P{da-GSGAL4.T} (Tricoire et al., 2009, Tricoire et al., 2009, Rera et al., 2010, Goguel et al., 2011, Slack et al., 2011, Paik et al., 2012, Sun et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	developmental rate defective \| RU486 conditional, with CG4769^GD3851 (Rera et al., 2010) developmental rate defective \| RU486 conditional, with CG9140^GD5335 (Rera et al., 2010) developmental rate defective \| RU486 conditional, with COQ7^GD8325 (Rera et al., 2010) developmental rate defective \| RU486 conditional, with CoVb^GD6659 (Rera et al., 2010) developmental rate defective \| RU486 conditional, with Lon^GD14030 (Rera et al., 2010) developmental rate defective \| RU486 conditional, with mRpL50^GD4975 (Rera et al., 2010) developmental rate defective \| RU486 conditional, with Oscp^GD4768 (Rera et al., 2010) female sterile \| RU486 conditional, with ATPsyn-β^GD4967 (Rera et al., 2010) female sterile \| RU486 conditional, with CoVb^GD6659 (Rera et al., 2010) female sterile \| RU486 conditional, with Oscp^GD4768 (Rera et al., 2010) lethal, with CG10209^GX193 (Paik et al., 2012) lethal, with cv-2^GX6589 (Paik et al., 2012) lethal, with dan^GX7554 (Paik et al., 2012) lethal, with PGRP-LC^GX6548 (Paik et al., 2012) lethal, with RapGAP1^GX5503-1 (Paik et al., 2012) lethal \| RU486 conditional, with CG9140^GD5335 (Rera et al., 2010) lethal \| RU486 conditional, with CoVb^GD6659 (Rera et al., 2010) lethal \| RU486 conditional, with Oscp^GD4768 (Rera et al., 2010) long lived, with AGBE^GX8331 (Paik et al., 2012) long lived, with AGBE^Scer\UAS.cPa (Paik et al., 2012) long lived, with CalpA^GX16168 (Paik et al., 2012) long lived, with CG8155^EP2612 (Paik et al., 2012) long lived, with CG10383^GX47642-1 (Paik et al., 2012) long lived, with CG10916^GX47642 (Paik et al., 2012) long lived, with CG30427^EP22086 (Paik et al., 2012) long lived, with CG42663^GX2970-1 (Paik et al., 2012) long lived, with Dlc90F^GX48290 (Paik et al., 2012) long lived, with ImpL2^GX4499 (Paik et al., 2012) long lived, with ImpL2^s.Scer\UAS (Paik et al., 2012) long lived, with InR^{K1409A.Scer\UAS} (Slack et al., 2011) long lived, with kis^GX2970 (Paik et al., 2012) long lived, with kis^GX6561 (Paik et al., 2012) long lived, with Men^EP1250 (Paik et al., 2012) long lived, with PGRP-LF^GX5503 (Paik et al., 2012) long lived, with SIFR^GX47280-1 (Paik et al., 2012) long lived, with Sin3A^GX8304 (Paik et al., 2012) long lived, with sm^GX21702-1 (Paik et al., 2012) long lived \| :drug conditional \| RU486 conditional, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Slack et al., 2011) long lived \| RU486 conditional, with InR^{K1409A.Scer\UAS} (Slack et al., 2011) long lived \| RU486 conditional, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Slack et al., 2011) semi-sterile \| RU486 conditional, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Slack et al., 2011) short lived, with ImpL2^s.Scer\UAS (Paik et al., 2012) short lived \| female \| RU486 conditional, with ATPsyn-β^GD4967 (Rera et al., 2010) short lived \| female \| RU486 conditional, with COQ7^GD8325 (Rera et al., 2010) short lived \| female \| RU486 conditional, with CoVb^GD6659 (Rera et al., 2010) short lived \| female \| RU486 conditional, with EcR^{B1-ΔC655.F645A.Scer\UAS} (Tricoire et al., 2009) short lived \| female \| RU486 conditional, with EcR^{B1-ΔC655.W650A.Scer\UAS} (Tricoire et al., 2009) short lived \| female \| RU486 conditional, with EcR^{dsRNA.Scer\UAS.cCa} (Tricoire et al., 2009) short lived \| female \| RU486 conditional, with Lon^GD14030 (Rera et al., 2010) short lived \| female \| RU486 conditional, with mRpL50^GD4975 (Rera et al., 2010) short lived \| female \| RU486 conditional, with Oscp^GD4768 (Rera et al., 2010) short lived \| male \| RU486 conditional, with CoVb^GD6659 (Rera et al., 2010) short lived \| male \| RU486 conditional, with Lon^GD14030 (Rera et al., 2010) short lived \| male \| RU486 conditional, with mRpL50^GD4975 (Rera et al., 2010) short lived \| male \| RU486 conditional, with Oscp^GD4768 (Rera et al., 2010) viable \| RU486 conditional, with Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (Slack et al., 2011)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference InR^{K1409A.Scer\UAS}, Scer\GAL4^da.Switch.PT has long lived \| RU486 conditional phenotype, suppressible by foxo^Δ94 (Slack et al., 2011) InR^{K1409A.Scer\UAS}, Scer\GAL4^da.Switch.PT has long lived phenotype, suppressible \| partially by foxo^Δ94 (Slack et al., 2011) Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^da.Switch.PT has long lived \| RU486 conditional phenotype, suppressible by foxo^Δ94 (Slack et al., 2011) Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^da.Switch.PT has long lived phenotype, suppressible \| partially by Scer\GAL4^da.Switch.PT (Slack et al., 2011, Slack et al., 2011)
NOT suppressed by
Statement Reference Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^da.Switch.PT has viable \| RU486 conditional phenotype, non-suppressible by foxo^Δ94 (Slack et al., 2011)
Suppressor of
Statement Reference Scer\GAL4^da.Switch.PT is a suppressor \| partially of long lived phenotype of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^da.Switch.PT (Slack et al., 2011, Slack et al., 2011)
NOT Suppressor of
Statement Reference InR^{K1409A.Scer\UAS}/Scer\GAL4^da.Switch.PT is a non-suppressor of viable \| RU486 conditional phenotype of foxo^Δ94 (Slack et al., 2011) Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}/Scer\GAL4^da.Switch.PT is a non-suppressor of viable \| RU486 conditional phenotype of foxo^Δ94 (Slack et al., 2011)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Scer\GAL4^da.Switch.PT
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245 Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389] Sun et al., 2012, Aging Cell 11(5): 783--793 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. [FBrf0219634] Goguel et al., 2011, J. Neurosci. 31(3): 1032--1037 Drosophila amyloid precursor protein-like is required for long-term memory. [FBrf0212809] Slack et al., 2011, Aging Cell 10(5): 735--748 dFOXO-independent effects of reduced insulin-like signaling in Drosophila. [FBrf0215229] Rera et al., 2010, Mech. Ageing Dev. 131(2): 156--164 Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. [FBrf0210048] Tricoire et al., 2009, Mech. Ageing Dev. 130(8): 547--552 The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner. [FBrf0208400]
Supplementary material	Tricoire et al., 2009, Mech. Ageing Dev. 130(8): Supplementary information: Materials and methods. [FBrf0212919]

Allele Scer\GAL4da.Switch.PT

Allele Scer\GAL4^da.Switch.PT