FB2025_01 , released February 20, 2025
Allele: Hsap\GALTUAS.cKa
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General Information
Symbol
Hsap\GALTUAS.cKa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Kushner
FlyBase ID
FBal0249089
Feature type
allele
Associated gene
Hsap\GALT
Associated Insertion(s)
Carried in Construct
P{UAS-hGALT.K}
Also Known As
UAS-hGALT
Key Links
Transgenic product class
wild_type
(Kushner et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kushner et al., 2010)
Mutagen
in vitro construct
(Kushner et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hGALT.K}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\GALT.

(Kushner et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\GALT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  galactosemia
      modeled by GaltΔ1AP2
      (Jumbo-Lucioni et al., 2014, Kushner et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing the P{UAS-hGALT.K}10B22 insertion of Hsap\GALTScer\UAS.cKa under the control of Scer\GAL4Act5C.PI exhibit normal locomotor and climbing behaviors compared to controls.

      (Ryan et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\GALTScer\UAS.cKa under the control of Scer\GAL4da.G32 suppresses the rolling movement defects and the NMJ over-elaboration phenotypes seen in GaltΔ1AP2/GaltΔ1AP2 mutant larvae.

      (Jumbo-Lucioni et al., 2014)

      Expression of either one or two copies of the P{UAS-hGALT.K}10A11 insertion of Hsap\GALTScer\UAS.cKa is able to significantly suppress the locomotor phenotypes seen in homozygous GaltΔ1AP2 mutant flies even in the absence of a Scer\GAL4 driver. When the P{UAS-hGALT.K}10B22 insertion of Hsap\GALTScer\UAS.cKa is expressed under the control of Scer\GAL4Act5C.PI locomotor and climbing behavior is comparable to controls.

      (Ryan et al., 2012)

      Expression of Hsap\GALTScer\UAS.cKa driven by Scer\GAL4tub.PU rescues the galactose-dependent lethality in GALTΔ1AP2 homozygotes.

      Expression of Hsap\GALTScer\UAS.cKa driven by Scer\GAL4tub.PU rescues the abnormal geotactic response in GALTΔ1V2 homozygotes.

      (Kushner et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\GALTScer\UAS.cKa
      Hsap\GALTUAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kushner
      Secondary FlyBase IDs
        References (3)