Open Close
General Information
Symbol
Dmel\AGO2454
Species
D. melanogaster
Name
FlyBase ID
FBal0249326
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

5750 bp deletion resulting from the imprecise excision of P{EP}AGO2EP3417, which removes most of AGO2 but not the adjacent genes.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion resulting in a deletion of 5750bp.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The fertility of AGO2454/Df(3L)BSC558 mutant males is severely reduced compared to wild-type controls (female fertility is not affected) due decreased number of mature sperm in their seminal vesicles. The spermatid nuclear alignment as well as the alignment of the investment cones in the testes is strongly disrupted.

AGO2454 homozygotes are short lived compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Embryos derived from dop1/AGO2454 transheterozygous females hatch and have a normal pattern lipid-droplet distribution.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The severely reduced fertility of AGO2454/Df(3L)BSC558 mutant males along with their sperm deficiency is rescued by combination with AGO2T:Zzzz\FLAG,T:Ivir\HA1.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)