FB2025_01 , released February 20, 2025
Allele: Dmel\AGO2454
Open Close
General Information
Symbol
Dmel\AGO2454
Species
D. melanogaster
Name
FlyBase ID
FBal0249326
Feature type
allele
Associated gene
Dmel\AGO2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Hain et al., 2010)
Progenitor genotype
P{EP}AGO2EP3417
(Hain et al., 2010)
Cytology
Description

Imprecise excision of the progenitor insertion resulting in a deletion of 5750bp.

(Hain et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:15,554,139..15,559,888 [+]
Comment:

5750 bp deletion resulting from the imprecise excision of P{EP}AGO2EP3417, which removes most of AGO2 but not the adjacent genes.

(Hain et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The fertility of AGO2454/Df(3L)BSC558 mutant males is severely reduced compared to wild-type controls (female fertility is not affected) due decreased number of mature sperm in their seminal vesicles. The spermatid nuclear alignment as well as the alignment of the investment cones in the testes is strongly disrupted.

      (Wen et al., 2015)

      AGO2454 homozygotes are short lived compared to controls.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      AGO2414/AGO2454 is a suppressor of abnormal eye color phenotype of wRNAi.GMR

      (Tanaka et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from dop1/AGO2454 transheterozygous females hatch and have a normal pattern lipid-droplet distribution.

      (Hain et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(3L)BSC558/AGO2454 is rescued by AGO2Tag:FLAG,Tag:HA

      (Wen et al., 2015)
      Comments

      The severely reduced fertility of AGO2454/Df(3L)BSC558 mutant males along with their sperm deficiency is rescued by combination with AGO2T:Zzzz\FLAG,T:Ivir\HA1.

      (Wen et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      dop1 complements AGO2454.

      (Hain et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AGO2454
      (Tanaka et al., 2024, Fort-Aznar et al., 2020, Ahlers et al., 2019)
      Ago2454
      (Li et al., 2013)
      ago2454
      (Iki et al., 2023, Wen et al., 2015, Hain et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)