Allele Hsap\TTR^{Scer\UAS.T:Zzzz\FLAG}

General Information
Symbol	Hsap\TTR^{Scer\UAS.T:Zzzz\FLAG}	Species	H. sapiens
Name		FlyBase ID	FBal0249333
Feature type	allele	Associated gene	Hsap\TTR

Allele class
Mutagen	in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Pokrzywa et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Hsap\TTR^Scer\UAS.cPa (Pokrzywa et al., 2010)
Nature of the lesion	Statement Reference A T:Zzzz\FLAG tag is inserted between the Hsap\TTR signal peptide and the rest of the Hsap\TTR sequence. (Pokrzywa et al., 2010)
Carried in construct	P{UAS-Hsap\TTR-FLAG} (Pokrzywa et al., 2010)
Tagged with	T:Zzzz\FLAG (Pokrzywa et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	glial cell, with Scer\GAL4^GMR.PF (Pokrzywa et al., 2010)
Detailed Description
	Statement Reference The size and organisation of the retina in flies expressing Hsap\TTR[Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PF] appears identical to that of normal control flies independent of age. Arrays of nanofilaments 7-9nm in thickness and nanospheres of about 20nm in diameter are abundant in the cytoplasm of glial cells that cover the surface of the retina (subretinal glia) and those that cover the surface of the brain (perineurial glia) in Hsap\TTR[Scer\UAS.T:Zzzz\FLAG]/+ and Hsap\TTR[Scer\UAS.T:Zzzz\FLAG]/Hsap\TTR[Scer\UAS.T:Zzzz\FLAG] (all under the control of Scer\GAL4[GMR.PF]) flies but not in wild-type flies. (Pokrzywa et al., 2010)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\TTR^{Scer\UAS.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Pokrzywa et al., 2010, PLoS ONE 5(12): e14343 Uptake of Aggregating Transthyretin by Fat Body in a Drosophila Model for TTR-Associated Amyloidosis. [FBrf0212549]

Allele Hsap\TTRScer\UAS.T:Zzzz\FLAG

Allele Hsap\TTR^{Scer\UAS.T:Zzzz\FLAG}